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Dennis P. Wall, PhD

Associate Professor, Department of Pathology, Harvard Medical School

Director of Computational Biology Initiative, Center for Biomedical Informatics, Harvard Medical School

Contact Info

Dennis Wall
Beth Israel Deaconess Medical Center
330 Brookline Avenue

Boston, MA, 02215
Phone: 617-432-3894
dpwall@hms.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Cutaneous Oncology and Melanoma
Cancer Genetics

Lab Website

Wall Lab

Research Abstract

Dr. Wall is interested in the design and application of translational bioinformatics tools to help bring whole-genomic data to the point of clinical care. His current areas of focus are in breast cancer, melanoma, lung and prostate cancer. As part of this focus, his lab is developing new techniques for the analysis of whole-genomic data, including fully sequenced tumor genomes and companion whole-genomic transcriptional assays, so that these data can be rapidly transformed into clinically actionable reports that yield prognostic predictions, drive decision support for alternative lines of therapy, and other medically actionable outcomes. He is currently building a databases of somatic and germline variants of known or probable clinical impact. This line of research is designed to complement and potentially supplant standard molecular diagnostics currently being used to characterize a patient’s cancer, with the intent to have a faster and more robust system in place for real-time genomic diagnostics. Dr. Wall co-directs and co-teaches courses in the analysis and clinical interpretation of next-generation sequence data and whole-genome analysis. He also co-directs the molecular pathology fellowship program at Beth Israel Deaconess Medical Center.

Publications

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