Dennis P. Wall, PhD
Associate Professor, Department of Pathology, Harvard Medical School
Director of Computational Biology Initiative, Center for Biomedical Informatics, Harvard Medical School
DF/HCC Program AffiliationCutaneous Oncology and MelanomaCancer Genetics
Lab WebsiteWall Lab
Dr. Wall is interested in the design and application of translational bioinformatics tools to help bring whole-genomic data to the point of clinical care. His current areas of focus are in breast cancer, melanoma, lung and prostate cancer. As part of this focus, his lab is developing new techniques for the analysis of whole-genomic data, including fully sequenced tumor genomes and companion whole-genomic transcriptional assays, so that these data can be rapidly transformed into clinically actionable reports that yield prognostic predictions, drive decision support for alternative lines of therapy, and other medically actionable outcomes. He is currently building a databases of somatic and germline variants of known or probable clinical impact. This line of research is designed to complement and potentially supplant standard molecular diagnostics currently being used to characterize a patient’s cancer, with the intent to have a faster and more robust system in place for real-time genomic diagnostics. Dr. Wall co-directs and co-teaches courses in the analysis and clinical interpretation of next-generation sequence data and whole-genome analysis. He also co-directs the molecular pathology fellowship program at Beth Israel Deaconess Medical Center.
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