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Xu Wu, PhD

Assistant Professor, Department of Dermatology, Harvard Medical School

Principal Investigator, Cutaneous Biology Research Center, Massachusetts General Hospital

Contact Info

Xu Wu
Massachusetts General Hospital
149 13th Street

Charlestown, MA, 02129
Mailstop: RM 3219
Phone: 617-726-4438
Fax: 617-726-4453
xwu@cbrc2.mgh.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Cutaneous Oncology and Melanoma
Translational Pharmacology and Early Therapeutic Trials

Lab Website

Wu Lab website

Research Abstract

My research lies at the interface of chemistry and biology. We are using synthetic and medicinal chemistry methods to develop novel small molecule modulators of biological functions, aiming to 1).discover novel tools for stem cell and cancer biology; 2). pharmacologically identify and validate novel therapeutic targets; 3). discover novel signaling nodes, cross-talking and their physiological and pathological relevances. We use the combination of high throughput chemical screen, functional genomics and medicinal chemistry to discover new cancer targets and pharmacologically validate the new target. Specifically, we are developing small molecule modulators of Hedgehog, Wnt, and Hippo signaling, and study the differentiation and cellular senescence of various cancer cells.

Publications

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