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Lee Gehrke, PhD

Professor, Department of Health Sciences and Technology, Harvard Medical School

Professor, Department of Microbiology and Immunobiology, Harvard Medical School

Professor, Inst. for Med. Engineering & Sci., Massachusetts Institute of Technology

Contact Info

Lee Gehrke
Harvard Medical School
77 Massachusetts Avenue
Cambridge, MA, 02139
Mailstop: MIT Building E25-406
Phone: 617-253-7608
Fax: 509-357-7835


Not Available.

DF/HCC Program Affiliation

Gastrointestinal Malignancies
Cancer Immunology

Research Abstract

My laboratory is interested in finding ways to prevent hepatitis C virus (HCV) infections from developing into liver cancer (hepatocellular carcinoma). HCV infections affect large numbers of people, and many infections progress to liver cancer. Our research is directed at activating the innate immune system, which is also linked to pathways that destroy cells, called apoptotic mechanisms. We use small RNA molecules to activate innate immune responses, and experiments are directed at determining if apoptotic responses are also activated. By using small RNAs to activate innate immunity and apoptosis, it may be possible to deliver a double attack to HCV-infected cells that could destroy infected cells before they can progress to cancerous cells.


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