Richard Blumberg, MD

Professor, Department of Medicine, Harvard Medical School

Chief, Division of Gastroenterology, Hepatology and Endoscopy, Gastroenterology, Hepatology and Endoscopy, Brigham And Women's Hospital

Contact Info

Richard Blumberg
Brigham and Women's Hospital
75 Francis Street
Boston, MA, 02115
Mailstop: Thorn 1419
Phone: 617-732-6917
rblumberg@partners.org

Assistant

Leanne Paradiso
Brigham And Women's Hospital
Phone: 617-732-5824
lparadiso@partners.org

DF/HCC Program Affiliation

Gastrointestinal Malignancies
Cancer Immunology

Lab Website

Blumberg Lab Website

Research Abstract

Carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) has traditionally been viewed as an adhesion molecule associated with signal transduction pathways in epithelial surfaces that is involved in regulating epithelial cell growth and development. Recent work from this laboratory has revealed a role for CEACAM1 in regulating of T cell responses. The laboratory has found that CEACAM1 is expressed on activated T cells and regulates the activity of T cells in vitro and in vivo. This regulation of T cells by CEACAM1 is consistent with the signalling properties of this molecule and the possession of two immune receptor tyrosine-based inhibitory motifs in the cytoplasmic tail of this molecule. The laboratory is interested in defining the molecular mechanisms underlying co-inhibition of T cells by CEACAM1. This is of central importance to tumor immunity and its therapeutic implications.

Publications

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DF/HCC Directory Login Update Member Profile Change Account Settings Applying for Membership Benefits Requirements Responsibilities	Richard Blumberg, MD Professor, Department of Medicine, Harvard Medical School Chief, Division of Gastroenterology, Hepatology and Endoscopy, Gastroenterology, Hepatology and Endoscopy, Brigham And Women's Hospital Contact Info Richard Blumberg Brigham and Women's Hospital 75 Francis Street Boston, MA, 02115 Mailstop: Thorn 1419 Phone: 617-732-6917 rblumberg@partners.org Assistant Leanne Paradiso Brigham And Women's Hospital Phone: 617-732-5824 lparadiso@partners.org DF/HCC Program Affiliation Gastrointestinal Malignancies Cancer Immunology Lab Website Blumberg Lab Website Research Abstract Carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) has traditionally been viewed as an adhesion molecule associated with signal transduction pathways in epithelial surfaces that is involved in regulating epithelial cell growth and development. Recent work from this laboratory has revealed a role for CEACAM1 in regulating of T cell responses. The laboratory has found that CEACAM1 is expressed on activated T cells and regulates the activity of T cells in vitro and in vivo. This regulation of T cells by CEACAM1 is consistent with the signalling properties of this molecule and the possession of two immune receptor tyrosine-based inhibitory motifs in the cytoplasmic tail of this molecule. The laboratory is interested in defining the molecular mechanisms underlying co-inhibition of T cells by CEACAM1. This is of central importance to tumor immunity and its therapeutic implications. Publications View All Publications
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