Joren C. Madsen, MD, PhD
Professor, Department of Surgery, Harvard Medical School
Co-Director, Transplantation Biology Research Center, Surgery, Massachusetts General Hospital
Director, MGH Transplant Center, Department of Surgery, Massachusetts General Hospital
DF/HCC Program AffiliationLeukemiaCancer Immunology
The risk of cancer in immunosuppressed transplant recipients is significantly elevated. Suppression of the immune system leads to decreased resistance to viral infection and associated increased risk of certain cancers, mainly those with a viral aetiology. In our laboratory, we are investigating ways to induce immune tolerance and allow allograft acceptance in patients in need of a transplant without the need for chronic immunosuppression. The goal of our investigations is to achieve a state of tolerance to the donor organ which will also assure that immune competence is maintained so that the risk of cancer is similar to that of the general public.
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