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Anyong Xie, PhD

Instructor, Department of Medicine, Harvard Medical School

Instructor, Medicine, Beth Israel Deaconess Medical Center

Contact Info

Anyong Xie
Beth Israel Deaconess Medical Center
330 Brookline Ave
Boston, MA, 02215
Mailstop: E/CLS 430
Phone: 617-735-2042
Fax: 617-735-2222
axie@bidmc.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Breast Cancer

Research Abstract

Aberrant repair of DNA double strand breaks (DSB) could cause genomic instability and ultimately human cancer. Among many different DSB repair mechanisms, a choice has to be made for proper repair. A major focus of my research is to understand how cells make a choice between homologous recombination (HR) and non-homologous end joining (NHEJ), two major DSB repair pathways, in mammalian DNA DSB repair. We are also interested in targeting NHEJ in breast cancer therapy. We are using high-throughput screening to identify new genes that regulate NHEJ and small molecular compounds that inhibit or stimulate this repair pathway. My long-term goal is to identify pre-therapeutic leads and develop them into breast cancer therapeutics.

Publications

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