Anyong Xie, PhD
Instructor, Department of Medicine, Harvard Medical School
Instructor, Medicine, Beth Israel Deaconess Medical Center
DF/HCC Program AffiliationBreast Cancer
Aberrant repair of DNA double strand breaks (DSB) could cause genomic instability and ultimately human cancer. Among many different DSB repair mechanisms, a choice has to be made for proper repair. A major focus of my research is to understand how cells make a choice between homologous recombination (HR) and non-homologous end joining (NHEJ), two major DSB repair pathways, in mammalian DNA DSB repair. We are also interested in targeting NHEJ in breast cancer therapy. We are using high-throughput screening to identify new genes that regulate NHEJ and small molecular compounds that inhibit or stimulate this repair pathway. My long-term goal is to identify pre-therapeutic leads and develop them into breast cancer therapeutics.
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