DF/HCC Program Affiliation

Cancer Genetics

Research Abstract

Dr. Beier has focused his research on the utilization of the mouse as a model of human disease and development. His work has encompassed all aspects of mammalian genetic analysis, including genetic mapping, positional cloning, mutagenesis, and complex trait analysis. A major present effort is the use of ENU mutagenesis to investigate mammalian development

Publications

• Ackerman KG, Wang J, Luo L, Fujiwara Y, Orkin SH, Beier DR.Gata4 is necessary for normal pulmonary lobar development.Am J Respir Cell Mol Biol 2007 Apr;36(4):391-7.
  17142311
• Ideraabdullah FY, Kim K, Pomp D, Moran JL, Beier D, Villena FP.Rescue of the Mouse DDK Syndrome by Parent-of-Origin-Dependent Modifiers.Biol Reprod 2007 Feb;76(2):286-293.
  17050856
• Holland KD, Fleming MT, Cheek S, Moran JL, Beier DR, Meisler MH.De novo exon duplication in a new allele of mouse Glra1 (spasmodic).Genetics 2006 Dec;174(4):2245-7.
  17028313
• Lehoczky JA, Cai WW, Douglas JA, Moran JL, Beier DR, Innis JW.Description and genetic mapping of Polypodia: an X-linked dominant mouse mutant with ectopic caudal limbs and other malformations.Mamm Genome 2006 Sep;17(9):903-13.
  16964440
• Smith LA, Bukanov NO, Husson H, Russo RJ, Barry TC, Taylor AL, Beier DR, Ibraghimov-Beskrovnaya O.Development of polycystic kidney disease in juvenile cystic kidney mice: insights into pathogenesis, ciliary abnormalities, and common features with human di
  16928806
• Moran JL, Bolton AD, Tran PV, Brown A, Dwyer ND, Manning DK, Bjork BC, Li C, Montgomery K, Siepka SM, Vitaterna MH, Takahashi JS, Wiltshire T, Kwiatkowski DJ, Kucherlapati R, Beier DR.Utilization of a whole genome SNP panel for efficient genetic mapping i
  16461637
• Ackerman KG, Herron BJ, Vargas SO, Huang H, Tevosian SG, Kochilas L, Rao C, Pober BR, Babiuk RP, Epstein JA, Greer JJ, Beier DR.Fog2 is required for normal diaphragm and lung development in mice and humans.PLoS Genet 2005 Jul;1(1):58-65.
  16103912
• Herron BJ, Rao C, Liu S, Laprade L, Richardson JA, Olivieri E, Semsarian C, Millar SE, Stubbs L, Beier DR.A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice.Hum Mol Genet 2005 Mar 1;14(5):667-77.
  15661756
• Ackerman KG, Huang H, Grasemann H, Puma C, Singer JB, Hill AE, Lander E, Nadeau JH, Churchill GA, Drazen JM, Beier DR.Interacting genetic loci cause airway hyperresponsiveness.Physiol Genomics 2005 Mar 21;21(1):105-11.
  15657107
• Liu S, Lu W, Obara T, Kuida S, Lehoczky J, Dewar K, Drummond IA, Beier DR.A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.Development 2002 Dec;129(24):5839-46.
  12421721
• Herron BJ, Lu W, Rao C, Liu S, Peters H, Bronson RT, Justice MJ, McDonald JD, Beier DR.Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis.Nat Genet 2002 Feb;30(2):185-9.
  11818962