Edward C. Stack, PhD
Instructor, Department of Pathology, Harvard Medical School
Associate Director, CMOP, Medical Oncology, Dana-Farber Cancer Institute
DF/HCC Program AffiliationGastrointestinal MalignanciesProstate Cancer
Lab WebsiteDFCI/BWH Center for Molecular Oncologic Pathology
As a cancer survivor, the molecular mechanisms driving the progression of cancer are the primary focus of my research interests. In prostate cancer, I am interested in the heterogeneous nature of prostate tumor biology from both a transcriptome and expression vantage point, with a particular interest in the roles of metabolism in driving the cancer phenotype, while in esophageal adenocarcinoma, I am interested in the molecular events that assist in driving dysplasia's to carcinomas. Lastly, I am interested in the general transcriptional anomalies present in gastrointestinal tumors, with the hope of developing use biomarker that will aid in diagnoses as well as guide potential therapeutic interventions. These are all supported by my role as the Associate Director of the Center for Molecular Oncologic Pathology, where interests in the pathological alterations which present in human prostate cancer, and the molecular phenotype undergirding cancer cell biology to allow for unchecked tumor growth in cancer is supported by expertise in molecular mechanisms of human diseases. I am able to leverage a combination of molecular biological, biochemical, histological, and pharmacological strengths in order to investigate molecular cascades affecting pathogenesis in oncologic disease, thus promoting continued development of therapeutic potential.
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