DF/HCC Program Affiliation

Leukemia

Lab Website

Kentsis Lab

Research Abstract

Our current work focuses on aberrant signaling and gene expression in high-risk myeloid leukemias and renal tumors, and we have made new discoveries linking receptor co-activation to aberrant autocrine signaling of acute myeloid leukemia cells, which has direct implications to overcoming resistance to targeted therapy. We are currently directing efforts to determine the molecular mechanisms of genomic plasticity and adaptation to targeted therapy using functional investigation of human tumors and engineered animal models, with the long-term goal of developing rational combination therapy of high-risk pediatric cancers. Another area of research is continued development of proteomics approaches for the discovery of new diagnostic markers and therapeutic targets, with application to acute inflammatory diseases and tumors: http://urineproteomics.org

Publications

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