Martin E. Dorf, PhD, MPP
Professor, Department of Microbiology and Immunobiology, Harvard Medical School
DF/HCC Program AffiliationCancer ImmunologyCancer Cell Biology
Cell migration into inflamed sites is the result of a complex set of molecularly distinguishable signals. A family of chemoattractant cytokines, termed chemokines, released at the focus of tissue injury attract circulating leukocytes. Chemokines induce leukocyte migration and activation by binding to a family of G protein-coupled receptors that are differentiallyexpressed on various target cells. The expression of most chemokine receptors is restricted to leukocytes. In addition, some chemokine receptors are constitutively expressed while products of the inflammatory response regulate the expression of others. This laboratory has cloned and characterized several murine chemokines and chemokine receptors involved in physiologic and pathologic responses. Particular attention is focused on those chemokines that are expressed in the central nervous system, including those associated with chronic inflammatory diseases or cell survival. We have also used chemokines as a cancer therapeutic.
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