DF/HCC Program Affiliation

Cutaneous Oncology and Melanoma

Research Abstract

Our main research contributions have been in the fields of multistep carcinogenesis, and in signal transduction, cell cycle control mechanisms underlying the switch between keratinocyte growth differentiation. In particular, over the last few years my laboratory has played a significant role in two major areas : 1) Tyrosine and phosphorylation in keratinocyte differentiation control and 2) The role of the cyclin dependent kinase inhibitor p21Cip1/WAF1 in growth/differentiation control and tumorigenesis.

Publications

• Calautti E, Cabodi S, Stein PL, Hatzfeld M, Kedersha N, Paolo Dotto G.Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion.J Cell Biol 1998 Jun 15;141(6):1449-65.
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• Di Cunto F, Topley G, Calautti E, Hsiao J, Ong L, Seth PK, Dotto GP.Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control.Science 1998 May 15;280(5366):1069-72.
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