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Christophe Benoist, MD, PhD

Morton Grove-Rasmussen Professor of Immunohematology, Department of Microbiology and Immunobiology, Harvard Medical School

Contact Info

Christophe Benoist
Harvard Medical School
77 Ave Louis Pasteur
Boston, MA, 02215
Mailstop: Room NRB-1052
Phone: 617-432-7741
Fax: 617-264-2744
cb@hms.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Cancer Immunology

Research Abstract

Our lab works in the fields of T cell differentiation and Autoimmunity, with a special emphasis on exploiting the most advanced transgenic and gene-targeting technology to engineer new mouse models. Studies on T cell differentiation focus on 1) selection of the T cell repertoire, in particular the cellular and molecular mechanisms of positive and negative selection and lineage commitment; and 2) cellular and molecular influences on naive T cell survival in the periphery. Studies on Autoimmunity explore the immunological mechanisms of diabetes and rheumatoid arthritis. Major questions tackled are what initiates these diseases, how is their progression regulated, and what are the final effector mechanisms. In addition, modern genetic approaches are used to identify disease modifying genes.

Publications

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