DF/HCC Program Affiliation

Neuro-Oncology
Translational Pharmacology and Early Therapeutic Trials
Lymphoma and Myeloma

Research Abstract

Dr. Hochberg's interests include Brain Lymphoma, gene therapy for glioma and the use of phase 1 and phase 2 agents to treat glioblastoma. He is the P.I. of an NCI-PO1 (Gene Therapy for Brain Tumors) which explores novel herpes vector systems expressing pro-drug activating transgenes. In addition he has been the PI of an NCI Consortium award to the Massachusetts General Hospital for the study of novel therapies of malignant brain tumors. Current research activities include the evaluation of risk factors for the development and progression of brain lymphoma including analyses of subtle alterations of cell-mediated immunity that might predispose to tumor development in "immunocompetent" individuals, the role of IgH rearrangement, the role of sustained EBViral infections (E. Kieff). Translational trials include therapies employing novel viral vectors (herpes, Adenoviral) expressing tk and interferon transgenes; novel phase 1 agents including camptothecins, antifols and angiogenesis inhibitors. These trials make use of novel surrogates of drug delivery including microdialysis probes and imaging of tumor blood flow, blood volume and permeability.

Publications

• Baehring JM, Hochberg FH, Betensky RA, Longtine J, Sklar J.Immunoglobulin gene rearrangement analysis in cerebrospinal fluid of patients with lymphoproliferative processes.J Neurol Sci 2006 Jun 7.
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• Baehring JM, Hochberg FH.Primary lymphoma of the nervous system.Cancer J 2006 Jan-Feb;12(1):1-13.
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• Stern BV, Baehring JM, Kleopa KA, Hochberg FH.Multifocal motor neuropathy with conduction block associated with metastatic lymphoma of the nervous system.J Neurooncol 2006 May;78(1):81-4.
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• Shah GD, Kesari S, Xu R, Batchelor TT, O'Neill AM, Hochberg FH, Levy B, Bradshaw J, Wen PY.Comparison of linear and volumetric criteria in assessing tumor response in adult high-grade gliomas.Neuro-oncol 2006 Jan;8(1):38-46.
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• Alderson L, Fetell MR, Sisti M, Hochberg F, Cohen M, Louis DN.Sentinel lesions of primary CNS lymphoma.J Neurol Neurosurg Psychiatry 1996 Jan;60(1):102-5.
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• Wei MX, Tamiya T, Chase M, Boviatsis EJ, Chang TK, Kowall NW, Hochberg FH, Waxman DJ, Breakefield XO, Chiocca EA.Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene.Hum Gene Ther 1994 Aug;5(8):969-78.
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• Glass J, Gruber ML, Cher L, Hochberg FH.Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma: long-term outcome.J Neurosurg 1994 Aug;81(2):188-95.
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