DF/HCC Program Affiliation

Cancer Genetics
Prostate Cancer

Research Abstract

Many of the common risk alleles discovered to date in genome wide association scans are located in non-protein coding regions. A primary focus of our laboratory is to understand the gene or genes that these variants are acting through. We are adopting a variety of approaches and techniques to develop an approach that will inform our understanding of the functional consequences of risk alleles that are outside of protein coding regions. Another focus of the laboratory is to gain a deeper understanding of the link between the germline and tumor genomes.

Publications

• Haiman CA, Patterson N, Freedman ML, Myers SR, Pike MC, Waliszewska A, Neubauer J, Tandon A, Schirmer C, McDonald GJ, Greenway SC, Stram DO, Le Marchand L, Kolonel LN, Frasco M, Wong D, Pooler LC, Ardlie K, Oakley-Girvan I, Whittemore AS, Cooney KA, John
  17401364
• Tamimi RM, Cox DG, Kraft P, Pollak MN, Haiman CA, Cheng I, Freedman ML, Hankinson SE, Hunter DJ, Colditz GA.Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study.Breast Cancer Res 2007;9(1):R18
  17300730
• de Bakker PI, Burtt NP, Graham RR, Guiducci C, Yelensky R, Drake JA, Bersaglieri T, Penney KL, Butler J, Young S, Onofrio RC, Lyon HN, Stram DO, Haiman CA, Freedman ML, Zhu X, Cooper R, Groop L, Kolonel LN, Henderson BE, Daly MJ, Hirschhorn JN, Altshuler
  17057720
• Cox DG, Blanche H, Pearce CL, Calle EE, Colditz GA, Pike MC, Albanes D, Allen NE, Amiano P, Berglund G, Boeing H, Buring J, Burtt N, Canzian F, Chanock S, Clavel-Chapelon F, Feigelson HS, Freedman M, Haiman CA, Hankinson SE, Henderson BE, Hoover R, Hunter
  16987421
• Freedman ML, Haiman CA, Patterson N, McDonald GJ, Tandon A, Waliszewska A, Penney K, Steen RG, Ardlie K, John EM, Oakley-Girvan I, Whittemore AS, Cooney KA, Ingles SA, Altshuler D, Henderson BE, Reich D.From the Cover: Admixture mapping identifies 8q24 as
  16945910
• Feigelson HS, Cox DG, Cann HM, Wacholder S, Kaaks R, Henderson BE, Albanes D, Altshuler D, Berglund G, Berrino F, Bingham S, Buring JE, Burtt NP, Calle EE, Chanock SJ, Clavel-Chapelon F, Colditz G, Diver WR, Freedman ML, Haiman CA, Hankinson SE, Hayes RB,
  16489054
• Cheng I, Stram DO, Penney KL, Pike M, Le Marchand L, Kolonel LN, Hirschhorn J, Altshuler D, Henderson BE, Freedman ML.Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort.J Natl Cancer Inst 2006 Jan 18;98(2):123-34.
  16418515
• Freedman ML, Penney KL, Stram DO, Riley S, McKean-Cowdin R, Le Marchand L, Altshuler D, Haiman CA.A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk.Cancer Res 2005 Aug 15;65(16):7516-22.
  16103107