DF/HCC Program Affiliation

Cancer Imaging
Neuro-Oncology

Research Abstract

My primary research focus is on the molecular imaging of neurological diseases. We have developed the first small-chelate MR agent targeting myeloperoxidase, an enzyme secreted by neutrophils and macrophages in cancers and other inflammatory diseases. By imaging the inflammatory response surrounding tumors, we may be able to increase our diagnostic sensitivity in detection and in evaluating treatment response. In addition to small-chelate agents, we also employ novel iron-oxide nanoparticle MR agents and optical methods to improve the imaging of oncological diseases.

Publications

• Zhu H,Acquaviva J,Ramachandran P,Boskovitz A,Woolfenden S,Pfannl R,Bronson RT,Chen JW,Weissleder R,Housman DE,Charest A.Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.Proc Natl Acad Sci U S A 2009 Feb 24;
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• McCann CM,Waterman P,Figueiredo JL,Aikawa E,Weissleder R,Chen JW.Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.Neuroimage 2009 Apr 1;45(2):360-9.
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• Breckwoldt MO,Chen JW,Stangenberg L,Aikawa E,Rodriguez E,Qiu S,Moskowitz MA,Weissleder R.Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase.Proc Natl Acad Sci U S A 2008 Nov 25;105(47):18584-9.
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• Chen JW,Breckwoldt MO,Aikawa E,Chiang G,Weissleder R.Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.Brain 2008 Apr;131(Pt 4):1123-33.
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• Chen JW, Querol Sans M, Bogdanov A, Weissleder R.Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates.Radiology 2006 Aug;240(2):473-81.
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• Tannous BA, Grimm J, Perry KF, Chen JW, Weissleder R, Breakefield XO.Metabolic biotinylation of cell surface receptors for in vivo imaging.Nat Methods 2006 May;3(5):391-6.
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• Chen JW, Pham W, Weissleder R, Bogdanov A.Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis.Magn Reson Med 2004 Nov;52(5):1021-8.
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