DF/HCC Program Affiliation

Cancer Genetics

Research Abstract

We study molecular pathways underlying one of the most common human genetic diseases, neurofibromatosis type 1 (NF1). To identify in vivo functions of the NF1 tumor suppressor, we have created a Drosophila model of this disease. We are also interested in identifying genes that modify tumor burden in human NF1 patients.

Publications

• Balenci L, Saoudi Y, Grunwald D, Deloulme JC, Bouron A, Bernards A, Baudier J.IQGAP1 regulates adult neural progenitors in vivo and vascular endothelial growth factor-triggered neural progenitor migration in vitro.J Neurosci 2007 Apr 25;27(17):4716-24.
  17460084
• Walker JA, Bernards A.Drosophila melanogaster neurofibromatosis-1: ROS, not Ras?.Nat Genet 2007 Apr;39(4):443-5.
  17392804
• Walker JA, Tchoudakova AV, McKenney PT, Brill S, Wu D, Cowley GS, Hariharan IK, Bernards A.Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.Genes D
  17114577
• Bernards A.Ras superfamily and interacting proteins database.Methods Enzymol 2005;407:1-9.
  16757309
• Bernards A, Settleman J.GAPs in growth factor signalling.Growth Factors 2005 Jun;23(2):143-9.
  16019436
• Bernards A, Settleman J.GAP control: regulating the regulators of small GTPases.Trends Cell Biol 2004 Jul;14(7):377-85.
  15246431
• Bernards A.GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila.Biochim Biophys Acta 2003 Mar 17;1603(2):47-82.
  12618308
• Tong J, Hannan F, Zhu Y, Bernards A, Zhong Y.Neurofibromin regulates G protein-stimulated adenylyl cyclase activity.Nat Neurosci 2002 Feb;5(2):95-6.
  11788835
• Williams JA, Su HS, Bernards A, Field J, Sehgal A.A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK.Science 2001 Sep 21;293(5538):2251-6.
  11567138
• Bernards A, Hariharan IK.Of flies and men--studying human disease in Drosophila.Curr Opin Genet Dev 2001 Jun;11(3):274-8.
  11377963
• The I, Hannigan GE, Cowley GS, Reginald S, Zhong Y, Gusella JF, Hariharan IK, Bernards A.Rescue of a Drosophila NF1 mutant phenotype by protein kinase A.Science 1997 May 2;276(5313):791-4.
  9115203
• Guo HF, The I, Hannan F, Bernards A, Zhong Y.Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides.Science 1997 May 2;276(5313):795-8.
  9115204