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Harold F. Dvorak, MD

Mallinckrodt Distinguished Professor of Pathology, Department of Pathology, Harvard Medical School

Chief, Pathology, Beth Israel Deaconess Medical Center

Contact Info

Harold Dvorak
Beth Israel Deaconess Medical Center
330 Brookline Avenue, RN227
Boston, MA, 02215
Mailstop: Research North 227
Phone: 617-667-8529
Fax: 617-667-2913


Nicole Magner
Administrative Associate
Beth Israel Deaconess Medical Center
Phone: 617-667-0654
Fax: 617-667-2913

DF/HCC Program Affiliation

Angiogenesis, Invasion and Metastasis

Research Abstract

Dr. Dvorak's current research interests:

1. Steps and mechanisms of VPF/VEGF-mediated angiogenesis, particularly the role of vascular hyperpermeability in this process.

2. Anatomic (ultrastructural) and signaling pathways of microvascular hyperpermeability in tumor microvessels and in normal microvessels stimulated by VPF/VEGF.

3. Generation of new blood vessels with the properties of mature normal vessels (in contrast to the immature, poorly differentiated vessels induced in tumors, wounds, etc.) as an approach to tissue (heart, legs) ischemia.

4. Vascular targeting as an approach to tumor therapy.


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