Harold F. Dvorak, MD
Mallinckrodt Distinguished Professor of Pathology, Department of Pathology, Harvard Medical School
Chief, Pathology, Beth Israel Deaconess Medical Center
DF/HCC Program AffiliationAngiogenesis, Invasion and Metastasis
Research AbstractDr. Dvorak's current research interests:
1. Steps and mechanisms of VPF/VEGF-mediated angiogenesis, particularly the role of vascular hyperpermeability in this process.
2. Anatomic (ultrastructural) and signaling pathways of microvascular hyperpermeability in tumor microvessels and in normal microvessels stimulated by VPF/VEGF.
3. Generation of new blood vessels with the properties of mature normal vessels (in contrast to the immature, poorly differentiated vessels induced in tumors, wounds, etc.) as an approach to tissue (heart, legs) ischemia.
4. Vascular targeting as an approach to tumor therapy.