DF/HCC Program Affiliation

Angiogenesis, Invasion and Metastasis

Research Abstract

Dr. Dvorak's current research interests:

1. Steps and mechanisms of VPF/VEGF-mediated angiogenesis, particularly the role of vascular hyperpermeability in this process.

2. Anatomic (ultrastructural) and signaling pathways of microvascular hyperpermeability in tumor microvessels and in normal microvessels stimulated by VPF/VEGF.

3. Generation of new blood vessels with the properties of mature normal vessels (in contrast to the immature, poorly differentiated vessels induced in tumors, wounds, etc.) as an approach to tissue (heart, legs) ischemia.

4. Vascular targeting as an approach to tumor therapy.

Publications

• Epstein SE, Kornowski R, Fuchs S, Dvorak HF.Angiogenesis therapy: amidst the hype, the neglected potential for serious side effects.Circulation 2001 Jul 3;104(1):115-9.
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• Zeng H, Dvorak HF, Mukhopadhyay D.Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-
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• Basu S, Nagy JA, Pal S, Vasile E, Eckelhoefer IA, Bliss VS, Manseau EJ, Dasgupta PS, Dvorak HF, Mukhopadhyay D.The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor.Nat Med 2001 May;
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• Sundberg C, Nagy JA, Brown LF, Feng D, Eckelhoefer IA, Manseau EJ, Dvorak AM, Dvorak HF.Glomeruloid microvascular proliferation follows adenoviral vascular permeability factor/vascular endothelial growth factor-164 gene delivery.Am J Pathol 2001 Mar;158(3
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• Pettersson A, Nagy JA, Brown LF, Sundberg C, Morgan E, Jungles S, Carter R, Krieger JE, Manseau EJ, Harvey VS, Eckelhoefer IA, Feng D, Dvorak AM, Mulligan RC, Dvorak HF.Heterogeneity of the angiogenic response induced in different normal adult tissues by
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• Fu Y, Comella N, Tognazzi K, Brown LF, Dvorak HF, Kocher O.Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display.Gene 1999 Nov 15;240(1):157-63.
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• Dvorak HF, Nagy JA, Feng D, Brown LF, Dvorak AM.Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis.Curr Top Microbiol Immunol 1999;237:97-132.
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• Vasile E, Qu-Hong , Dvorak HF, Dvorak AM.Caveolae and vesiculo-vacuolar organelles in bovine capillary endothelial cells cultured with VPF/VEGF on floating Matrigel-collagen gels.J Histochem Cytochem 1999 Feb;47(2):159-67.
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• Feng D, Nagy JA, Pyne K, Dvorak HF, Dvorak AM.Platelets exit venules by a transcellular pathway at sites of F-met peptide-induced acute inflammation in guinea pigs.Int Arch Allergy Immunol 1998 Jul;116(3):188-95.
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• Carlson I, Tognazzi K, Manseau EJ, Dvorak HF, Brown LF.Osteopontin is strongly expressed by histiocytes in granulomas of diverse etiology.Lab Invest 1997 Jul;77(1):103-8.
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• Watanabe Y, Dvorak HF.Vascular permeability factor/vascular endothelial growth factor inhibits anchorage-disruption-induced apoptosis in microvessel endothelial cells by inducing scaffold formation.Exp Cell Res 1997 Jun 15;233(2):340-9.
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• Claffey KP, Brown LF, del Aguila LF, Tognazzi K, Yeo KT, Manseau EJ, Dvorak HF.Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis.Cancer Res 199
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• Senger DR, Connolly DT, Van de Water L, Feder J, Dvorak HF.Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor.Cancer Res 1990 Mar 15;50(6):1774-8.
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