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Rebecca A. Betensky, PhD


  • Taylor JW, Flanagan EP, O'Neill BP, Siegal T, Omuro A, Deangelis L, Baehring J, Nishikawa R, Pinto F, Chamberlain M, Hoang-Xuan K, Gonzalez-Aguilar A, Batchelor T, Blay JY, Korfel A, Betensky RA, Lopes MB, Schiff D.Primary leptomeningeal lymphoma: International Primary CNS Lymphoma Collaborative Group report.Neurology. 2013 Nov 5;81(19):1690-6.
  • Waikar SS, Betensky RA, Emerson SC, Bonventre JV.Imperfect gold standards for biomarker evaluation.Clin Trials. 2013;10(5):696-700.
  • Mi MY, Betensky RA.An analysis of adaptive design variations on the sequential parallel comparison design for clinical trials.Clin Trials. 2013;10(2):207-15.
  • Bijron JG, Ning G, Laury AR, Quick CM, Betensky RA, Monte NM, King E, McKeon FD, Xian W, Crum CP.Digital quantification of precursor frequency in the fallopian tube and its significance.Mod Pathol. 2012 Jul 6.
  • Mohapatra G, Engler DA, Starbuck KD, Kim JC, Bernay DC, Scangas GA, Rousseau A, Batchelor TT, Betensky RA, Louis DN.Genome-wide comparison of paired fresh frozen and formalin-fixed paraffin-embedded gliomas by custom BAC and oligonucleotide array comparative genomic hybridization: facilitating analysis of archival gliomas.Acta Neuropathol. 2011 Apr;121(4):529-43.
  • Abla O, Weitzman S, Blay JY, O'Neill BP, Abrey LE, Neuwelt E, Doolittle ND, Baehring J, Pradhan K, Martin SE, Guerrera M, Shah S, Ghesquieres H, Silver M, Betensky RA, Batchelor T.Primary CNS lymphoma in children and adolescents: a descriptive analysis from the international primary CNS lymphoma collaborative group (IPCG).Clin Cancer Res. 2011 Jan 15;17(2):346-52.
  • Spires-Jones TL, Kay K, Matsouka R, Rozkalne A, Betensky RA, Hyman BT.Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain.Neurosci Lett. 2011 Jan 10;487(3):260-3.
  • Desantis SM,Houseman EA,Coull BA,Louis DN,Mohapatra G,Betensky RA.A Latent Class Model with Hidden Markov Dependence for Array CGH Data.Biometrics. 2009 Dec;65(4):1296-305.
  • Stamoulis C, Betensky RA, Mohapatra G, Louis DN.Application of signal processing techniques for estimating regions of copy number variations in human meningioma DNA.Conf Proc IEEE Eng Med Biol Soc. 2009;2009:6973-6.
  • Gabeau-Lacet D, Engler D, Gupta S, Scangas GA, Betensky RA, Barker FG, Loeffler JS, Louis DN, Mohapatra G.Genomic profiling of atypical meningiomas associates gain of 1q with poor clinical outcome.J Neuropathol Exp Neurol. 2009 Oct;68(10):1155-65.
  • Waikar SS, Betensky RA, Bonventre JV.Creatinine as the gold standard for kidney injury biomarker studies?.Nephrol. Dial. Transplant. 2009 Nov;24(11):3263-5.
  • Snuderl M, Eichler AF, Ligon KL, Vu QU, Silver M, Betensky RA, Ligon AH, Wen PY, Louis DN, Iafrate AJ.Polysomy for chromosomes 1 and 19 predicts earlier recurrence in anaplastic oligodendrogliomas with concurrent 1p/19q loss.Clin Cancer Res. 2009 Oct 15;15(20):6430-7.
  • Gabeau-Lacet D,Aghi M,Betensky RA,Barker FG,Loeffler JS,Louis DN.Bone involvement predicts poor outcome in atypical meningioma.J Neurosurg. 2009 Sep;111(3):464-71.
  • Stankovic KM, Mrugala MM, Martuza RL, Silver M, Betensky RA, Nadol JB, Stemmer-Rachamimov AO.Genetic determinants of hearing loss associated with vestibular schwannomas.Otol. Neurotol. 2009 Aug;30(5):661-7.
  • Shen Y, Nunes F, Stemmer-Rachamimov A, James M, Mohapatra G, Plotkin S, Betensky RA, Engler DA, Roy J, Ramesh V, Gusella JF.Genomic profiling distinguishes familial multiple and sporadic multiple meningiomas.BMC Med Genomics. 2009;2:42.
  • Vaidya VS,Waikar SS,Ferguson MA,Collings FB,Sunderland K,Gioules C,Bradwin G,Matsouaka R,Betensky RA,Curhan GC,Bonventre JV.Urinary Biomarkers for Sensitive and Specific Detection of Acute Kidney Injury in Humans.Clin Transl Sci. 2008 Dec;1(3):200-208.
  • Mandel M, Betensky RA.Estimating time-to-event from longitudinal ordinal data using random-effects Markov models: application to multiple sclerosis progression.Biostatistics. 2008 Oct;9(4):750-64.
  • Patil S, Perry A, Maccollin M, Dong S, Betensky RA, Yeh TH, Gutmann DH, Stemmer-Rachamimov AO.Immunohistochemical Analysis Supports a Role for INI1/SMARCB1 in Hereditary Forms of Schwannomas, but Not in Solitary, Sporadic Schwannomas.Brain Pathol. 2008 Oct;18(4):517-9.
  • Zhu JJ,Gerstner ER,Engler DA,Mrugala MM,Nugent W,Nierenberg K,Hochberg FH,Betensky RA,Batchelor TT.High-dose methotrexate for elderly patients with primary CNS lymphoma.Neuro-oncol. 2009 Apr;11(2):211-5.
  • Snuderl M,Chi SN,De Santis SM,Stemmer-Rachamimov AO,Betensky RA,De Girolami U,Kieran MW.Prognostic value of tumor microinvasion and metalloproteinases expression in intracranial pediatric ependymomas.J Neuropathol Exp Neurol. 2008 Sep;67(9):911-20.
  • Matthews AG,Finkelstein DM,Betensky RA.Analysis of familial aggregation studies with complex ascertainment schemes.Stat Med. 2008 Oct 30;27(24):5076-92.
  • Betensky RA, Louis DN, Cairncross JG.Tests of association under misclassification: Application to histological sampling in oncology.Stat Med. 2007 Nov 20;26(26):4808-16.
  • Voloschin AD, Betensky R, Wen PY, Hochberg F, Batchelor T.Topotecan as salvage therapy for relapsed or refractory primary central nervous system lymphoma.J Neurooncol. 2008 Jan;86(2):211-5.
  • Mandel M, Betensky RA.Testing goodness of fit of a uniform truncation model.Biometrics. 2007 Jun;63(2):405-12.
  • Desantis SM, Houseman EA, Coull BA, Stemmer-Rachamimov A, Betensky RA.A penalized latent class model for ordinal data.Biostatistics. 2008 Apr;9(2):249-62.
  • Li Y, Shih M, Betensky R.Designed extension of survival studies: Application to clinical trials with unrecognized heterogeneity.Stat Sin.;17:1567-1589.
  • Matthews AG, Finkelstein DM, Betensky RA.Multivariate logistic regression for familial aggregation in age at disease onset.Lifetime Data Analysis. 2007 Jun;13(2):191-209.
  • Cahill DP, Levine KK, Betensky RA, Codd PJ, Romany CA, Reavie LB, Batchelor TT, Futreal PA, Stratton MR, Curry WT, Iafrate AJ, Louis DN.Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment.Clin Cancer Res. 2007 Apr 1;13(7):2038-45.
  • Prada CM, Garcia-Alloza M, Betensky RA, Zhang-Nunes SX, Greenberg SM, Bacskai BJ, Frosch MP.Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging.J Neurosci. 2007 Feb 21;27(8):1973-80.
  • Li Y, Shih M, Betensky R.Designed Extension of Survival Studies: Applicatino to Clinical Trials with Unrecognized Heterogeneity.Stat Sin.;17:1567-1589.
  • Houseman EA, Coull BA, Betensky RA.Feature-specific penalized latent class analysis for genomic data.Biometrics. 2006 Dec;62(4):1062-70.
  • Rousseau A, Nutt CL, Betensky RA, Iafrate AJ, Han M, Ligon KL, Rowitch DH, Louis DN.Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.J Neuropathol Exp Neurol. 2006 Dec;65(12):1149-56.
  • Mizoguchi M, Betensky RA, Batchelor TT, Bernay DC, Louis DN, Nutt CL.Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival.J Neuropathol Exp Neurol. 2006 Dec;65(12):1181-8.
  • Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP.Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease.Neurobiol Dis. 2006 Dec;24(3):516-24.
  • Baehring JM, Hochberg FH, Betensky RA, Longtine J, Sklar J.Immunoglobulin gene rearrangement analysis in cerebrospinal fluid of patients with lymphoproliferative processes.J Neurol Sci. 2006 Sep 25;247(2):208-16.
  • Coull BA, Houseman EA, Betensky RA. A computationally tractable multivariate random effects model for clustered binary data.Biometrika.;93(3):587-599.
  • Houseman EA, Coull BA, Betensky RA.Feature-sepcific constrained latent class analysis for medium throughput genomic data.Survey Methodol. 2006 Sep 01;In Press.
  • Coull BA, Houseman EA, Betensky R.A computationally efficient multivariate random effects model for clustered binary data.Biometrika. 2006 Sep 01;93:587-599.
  • Pierie JP, Betensky RA, Choudry U, Willett CG, Souba WW, Ott MJ.Outcomes in a series of 103 retroperitoneal sarcomas.Eur J Surg Oncol. 2006 Dec;32(10):1235-41.
  • Betensky RA, Christian CK, Gustafson ML, Daley J, Zinner MJ.Hospital volume versus outcome: an unusual example of bivariate association.Biometrics. 2006 Jun;62(2):598-604.
  • Scholtens D, Betensky RA.A computationally simple bivariate survival estimator for efficacy and safety.Lifetime Data Analysis. 2006 Sep;12(3):365-87.
  • Zhang B, Li Y, Betensky RA.Effects of unmeasured heterogeneity in the linear transformation model for censored data.Lifetime Data Anal. 2006 Jun;12(2):191-203.
  • Goldfine AB, Beckman JA, Betensky RA, Devlin H, Hurley S, Varo N, Schonbeck U, Patti ME, Creager MA.Family history of diabetes is a major determinant of endothelial function.J Am Coll Cardiol. 2006 Jun 20;47(12):2456-61.
  • Riemenschneider MJ, Betensky RA, Pasedag SM, Louis DN.AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling.Cancer Res. 2006 Jun 1;66(11):5618-23.
  • Zhang B, Betensky RA.Methods to classify familial relationships in the presence of laboratory errors, without parental data.Hum Genet. 2006 Jul;119(6):642-8.
  • Mohapatra G, Betensky RA, Miller ER, Carey B, Gaumont LD, Engler DA, Louis DN.Glioma test array for use with formalin-fixed, paraffin-embedded tissue: array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ hybridization.J Mol Diagn. 2006 May;8(2):268-76.
  • Engler DA, Mohapatra G, Louis DN, Betensky RA.A pseudolikelihood approach for simultaneous analysis of array comparative genomic hybridizations.Biostatistics. 2006 Jul;7(3):399-421.
  • Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ.Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease.J Neurosci. 2006 Jan 11;26(2):365-71.
  • Ferrante KL, Shefner J, Zhang H, Betensky R, O'Brien M, Yu H, Fantasia M, Taft J, Beal MF, Traynor B, Newhall K, Donofrio P, Caress J, Ashburn C, Freiberg B, O'Neill C, Paladenech C, Walker T, Pestronk A, Abrams B, Florence J, Renna R, Schierbecker J, Malkus B, Cudkowicz M.Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS.Neurology. 2005 Dec 13;65(11):1834-6.
  • Dong S, Nutt CL, Betensky RA, Stemmer-Rachamimov AO, Denko NC, Ligon KL, Rowitch DH, Louis DN.Histology-Based Expression Profiling Yields Novel Prognostic Markers in Human Glioblastoma.J Neuropathol Exp Neurol. 2005 Nov;64(11):948-955.
  • Riemenschneider MJ, Mueller W, Betensky RA, Mohapatra G, Louis DN.In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation.Am J Pathol. 2005 Nov;167(5):1379-87.
  • Cantuti-Castelvetri I, Lin MT, Zheng K, Keller-McGandy CE, Betensky RA, Johns DR, Beal MF, Standaert DG, Simon DK.Somatic mitochondrial DNA mutations in single neurons and glia.Neurobiol Aging. 2005 Nov-Dec;26(10):1343-55.
  • Shih HA, Betensky RA, Dorfman MV, Louis DN, Loeffler JS, Batchelor TT.Genetic analyses for predictors of radiation response in glioblastoma.Int J Radiat Oncol Biol Phys. 2005 Nov 1;63(3):704-10.
  • Betensky RA, Nutt CL, Batchelor TT, Louis DN.Statistical considerations for immunohistochemistry panel development after gene expression profiling of human cancers.J Mol Diagn. 2005 May;7(2):276-82.
  • Nutt CL, Betensky RA, Brower MA, Batchelor TT, Louis DN, Stemmer-Rachamimov AO.YKL-40 is a differential diagnostic marker for histologic subtypes of high-grade gliomas.Clin Cancer Res. 2005 Mar 15;11(6):2258-64.
  • Plotkin SR, Betensky RA, Hochberg FH, Grossman SA, Lesser GJ, Nabors LB, Chon B, Batchelor TT.Treatment of relapsed central nervous system lymphoma with high-dose methotrexate.Clin Cancer Res. 2004 Sep 1;10(17):5643-6.
  • Fernandez-Teijeiro A, Betensky RA, Sturla LM, Kim JY, Tamayo P, Pomeroy SL.Combining gene expression profiles and clinical parameters for risk stratification in medulloblastomas.J Clin Oncol. 2004 Mar 15;22(6):994-8.
  • Batchelor TT, Betensky RA, Esposito JM, Pham LD, Dorfman MV, Piscatelli N, Jhung S, Rhee D, Louis DN.Age-dependent prognostic effects of genetic alterations in glioblastoma.Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):228-33.
  • Cai T, Betensky RA.Hazard regression for interval-censored data with penalized spline.Biometrics. 2003 Sep;59(3):570-9.
  • Christian CK, Gustafson ML, Betensky RA, Daley J, Zinner MJ.The Leapfrog volume criteria may fall short in identifying high-quality surgical centers.Ann Surg. 2003 Oct;238(4):447-55; discussion 455-7.
  • Baehring JM, Betensky RA, Batchelor TT.Malignant peripheral nerve sheath tumor: The clinical spectrum and outcome of treatment.Neurology. 2003 Sep 9;61(5):696-8.
  • Rabinowitz D, Betensky RA.Testing for familial correlation in age-at-onset.Biostatistics. 2002 Mar;3(1):77-85.
  • Betensky RA, Talcott JA, Weeks JC.Binary data with two, non-nested sources of clustering: an analysis of physician recommendations for early prostate cancer treatment.Biostatistics. 2000 Jun;1(2):219-30.
  • Betensky RA, Louis DN, Cairncross JG.Analysis of a molecular genetic neuro-oncology study with partially biased selection.Biostatistics. 2003 Apr;4(2):167-78.
  • Bai H, Cviko A, Granter S, Yuan L, Betensky RA, Crum CP.Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis.Hum Pathol. 2003 Jun;34(6):559-64.
  • Baehring JM, Damek D, Martin EC, Betensky RA, Hochberg FH.Neurolymphomatosis.Neuro-oncol. 2003 Apr;5(2):104-15.
  • Nutt CL, Mani DR, Betensky RA, Tamayo P, Cairncross JG, Ladd C, Pohl U, Hartmann C, McLaughlin ME, Batchelor TT, Black PM, von Deimling A, Pomeroy SL, Golub TR, Louis DN.Gene expression-based classification of malignant gliomas correlates better with survival than histological classification.Cancer Res. 2003 Apr 1;63(7):1602-7.
  • Braaten KM, Betensky RA, de Leval L, Okada Y, Hochberg FH, Louis DN, Harris NL, Batchelor TT.BCL-6 expression predicts improved survival in patients with primary central nervous system lymphoma.Clin Cancer Res. 2003 Mar;9(3):1063-9.
  • Bebchuk JD, Betensky RA.Local likelihood analysis of the latency distribution with interval censored intermediate events.Stat Med. 2002 Nov 30;21(22):3475-91.
  • Arboleda-Velasquez JF, Lopera F, Lopez E, Frosch MP, Sepulveda-Falla D, Gutierrez JE, Vargas S, Medina M, Martinez De Arrieta C, Lebo RV, Slaugenhaupt SA, Betensky RA, Villegas A, Arcos-Burgos M, Rivera D, Restrepo JC, Kosik KS.C455R notch3 mutation in a Colombian CADASIL kindred with early onset of stroke.Neurology. 2002 Jul 23;59(2):277-9.
  • Betensky RA, Louis DN, Cairncross JG.Influence of unrecognized molecular heterogeneity on randomized clinical trials.J Clin Oncol. 2002 May 15;20(10):2495-9.
  • Sasaki H, Betensky RA, Cairncross JG, Louis DN.DMBT1 polymorphisms: relationship to malignant glioma tumorigenesis.Cancer Res. 2002 Mar 15;62(6):1790-6.
  • Betensky RA, Finkelstein DM.Testing for dependence between failure time and visit compliance with interval-censored data.Biometrics. 2002 Mar;58(1):58-63.
  • Li Y, Betensky RA, Louis DN, Cairncross JG.The use of frailty hazard models for unrecognized heterogeneity that interacts with treatment: considerations of efficiency and power.Biometrics. 2002 Mar;58(1):232-6.
  • Sasaki H, Zlatescu MC, Betensky RA, Johnk LB, Cutone AN, Cairncross JG, Louis DN.Histopathological-molecular genetic correlations in referral pathologist-diagnosed low-grade "oligodendroglioma".J Neuropathol Exp Neurol. 2002 Jan;61(1):58-63.
  • Betensky RA, Lindsey JC, Ryan LM, Wand MP.A local likelihood proportional hazards model for interval censored data.Stat Med. 2002 Jan 30;21(2):263-75.
  • Zlatescu MC, TehraniYazdi A, Sasaki H, Megyesi JF, Betensky RA, Louis DN, Cairncross JG.Tumor location and growth pattern correlate with genetic signature in oligodendroglial neoplasms.Cancer Res. 2001 Sep 15;61(18):6713-5.
  • Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ.alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins.Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9110-5.
  • Sasaki H, Zlatescu MC, Betensky RA, Ino Y, Cairncross JG, Louis DN.PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis.Am J Pathol. 2001 Jul;159(1):359-67.
  • Betensky RA, Rabinowitz D.Maximally selected chi2 statistics for k x 2 tables.Biometrics. 1999 Mar;55(1):317-20.
  • Betensky RA, Lindsey JC, Ryan LM, Wand MP.Local EM estimation of the hazard function for interval-censored data.Biometrics. 1999 Mar;55(1):238-45.
  • Ino Y, Betensky RA, Zlatescu MC, Sasaki H, Macdonald DR, Stemmer-Rachamimov AO, Ramsay DA, Cairncross JG, Louis DN.Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis.Clin Cancer Res. 2001 Apr;7(4):839-45.
  • Betensky RA, Rabinowitz D.Simple approximations for the maximal transmission/disequilibrium test with a multi-allelic marker.Ann Hum Genet. 2000 Nov;64(Pt 6):567-74.
  • Betensky RA, Schoenfeld DA.Nonparametric estimation in a cure model with random cure times.Biometrics. 2001 Mar;57(1):282-6.
  • Hudson JI, Laird NM, Betensky RA, Keck PE, Pope HG.Multivariate logistic regression for familial aggregation of two disorders. II. Analysis of studies of eating and mood disorders.Am J Epidemiol. 2001 Mar 1;153(5):506-14.
  • Hudson JI, Laird NM, Betensky RA.Multivariate logistic regression for familial aggregation of two disorders. I. Development of models and methods.Am J Epidemiol. 2001 Mar 1;153(5):500-5.
  • Betensky RA, Hudson JI, Jones CA, Hu F, Wang B, Chen C, Xu X.A computationally simple test of homogeneity of odds ratios for twin data.Genet Epidemiol. 2001 Feb;20(2):228-38.
  • Rabinowitz D, Betensky RA.Approximating the distribution of maximally selected McNemar's statistics.Biometrics. 2000 Sep;56(3):897-902.
  • Betensky RA.On nonidentifiability and noninformative censoring for current status data.Biometrika. 2000 Jun;87(2):218-221.
  • Betensky RA.Redistribution algorithms for censored data.Survey Methodol. 2000 Feb 15;46(4):385-389.