Michael J. Eck, MD, PhD

Professor, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

Professor, Cancer Biology, Dana-Farber Cancer Institute

Contact Info

Michael Eck
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Mailstop: Smith 1036
Phone: 617-632-5860
Fax: 617-632-4393
eck@red.dfci.harvard.edu

Assistant

Kelly Judge
Administrative Specialist
Cancer Biology
Dana-Farber Cancer Institute
44 Binney Street
Boston, MA, 02115
Phone: 617-632-6488
Fax: 617-632-4393
Kelly_judge@dfci.harvard.edu

DF/HCC Program Affiliation

Lung Cancer
Cancer Cell Biology

Research Abstract

Structural biology of tyrosine kinase signaling and cancer. We use x-ray crystallography and other biophysical and biochemical methods to study the structure and regulation of tyrosine kinases and their disregulation in cancer. Particular interests include EGFR kinase mutations in lung cancer and Jak kinase mutations in myeloproliferative disorders. We are also interested focal adhesion kinase, and in structure-based approaches to development of new tyrosine kinase inhibitors.

Publications

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DF/HCC Directory Login Update Member Profile Change Account Settings Applying for Membership Benefits Requirements Responsibilities	Michael J. Eck, MD, PhD Professor, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School Professor, Cancer Biology, Dana-Farber Cancer Institute Contact Info Michael Eck Dana-Farber Cancer Institute 450 Brookline Avenue Boston, MA, 02215 Mailstop: Smith 1036 Phone: 617-632-5860 Fax: 617-632-4393 eck@red.dfci.harvard.edu Assistant Kelly Judge Administrative Specialist Cancer Biology Dana-Farber Cancer Institute 44 Binney Street Boston, MA, 02115 Phone: 617-632-6488 Fax: 617-632-4393 Kelly_judge@dfci.harvard.edu DF/HCC Program Affiliation Lung Cancer Cancer Cell Biology Research Abstract Structural biology of tyrosine kinase signaling and cancer. We use x-ray crystallography and other biophysical and biochemical methods to study the structure and regulation of tyrosine kinases and their disregulation in cancer. Particular interests include EGFR kinase mutations in lung cancer and Jak kinase mutations in myeloproliferative disorders. We are also interested focal adhesion kinase, and in structure-based approaches to development of new tyrosine kinase inhibitors. Publications View All Publications
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