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Ulrike S. Eggert, PhD

Assistant Professor, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School

Assistant Professor, Cancer Biology, Dana-Farber Cancer Institute

Contact Info

Ulrike Eggert
Harvard Medical School
250 Longwood Avenue
Boston, MA, 02115
Mailstop: SGMB 620
Phone: 617-582-8581
Fax: 617-582-8580
ulrike_eggert@dfci.harvard.edu

Assistant

Amanda Baker
Administrative Assistant
Biological Chemistry and Molecular Pharmacology
Harvard Medical School
250 Longwood Avenue
Boston, MA, 02115
Phone: 617-632-5012
amanda_baker@dfci.harvard.edu

DF/HCC Program Affiliation

Cancer Cell Biology

Research Abstract

The mechanism of cytokinesis, the final step in cell division, remains a major unsolved question in biology. We aim to understand how cells regulate and perform cytokinesis because it will give us insights into what goes wrong when cytokinesis fails and how failure and subsequent aneuploidy might be a cause or consequence of cancer. Our long-term goal is the systematic dissection of temporal and spatial control during cytokinesis. It has traditionally been challenging to study cytokinesis because it is a rapid process and many proteins also perform important functions earlier in the cell cycle. This is why small molecules, which act rapidly and with high temporal control, are ideal tools to study cytokinesis, but few active small molecules exist. We performed a screen to identify small molecule inhibitors of cytokinesis and are investigating several molecules with different and novel mechanisms of action. A major technological interest in the lab is the combination of RNAi and small molecule approaches. We are applying this strategy to discover small molecules that affect the Rho pathway, a key regulator of cytokinesis and other cellular processes. In addition to being useful tool compounds, our compounds may catalyze the development of cancer drugs.

Publications

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