DF/HCC Program Affiliation

Neuro-Oncology
Kidney Cancer

DF/HCC Associations

DFCI, Neuro-Oncology, Clinical Trial Chairs

Research Abstract

My research is directed towards the deveiopment of new therapies for brain tumors and leptomeningeal metastases using gene therapy, inhibitors of angiogenesis, hormonal therapy and radionuclides. I am also interested in the neurologic complications in cancer patients.

Publications

• Wen PY, DeAngelis LM.Chemotherapy for low-grade gliomas: emerging consensus on its benefits.Neurology 2007 May 22;68(21):1762-3.
  17515537
• Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK.The 1p-encoded protein stathmin and resistance of malignant gliomas to nit
  17440165
• Chi AS, Wen PY.Inhibiting kinases in malignant gliomas.Expert Opin Ther Targets 2007 Apr;11(4):473-96.
  17373878
• Chheda MG, Drappatz J, Greenberger NJ, Kesari S, Weiss SE, Gigas DC, Doherty LM, Wen PY.Hepatitis B reactivation during glioblastoma treatment with temozolomide: a cautionary note.Neurology 2007 Mar 20;68(12):955-6.
  17372135
• Narin O, Drappatz J, Doherty LM, Wen PY, Kesari S.Cerebrospinal fluid spread of anaplastic glioma.J Clin Oncol 2007 Feb 10;25(5):596-7.
  17290068
• Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK.AZD2171, a pan-VEGF receptor ty
  17222792
• Norden AD, Wen PY.Glioma therapy in adults.Neurologist 2006 Nov;12(6):279-92.
  17122724
• Maher EA, Brennan C, Wen PY, Durso L, Ligon KL, Richardson A, Khatry D, Feng B, Sinha R, Louis DN, Quackenbush J, Black PM, Chin L, DePinho RA.Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct mo
  17114236
• Wen PY, Drappatz J.Novel therapies for meningiomas.Expert Rev Neurother 2006 Oct;6(10):1447-64.
  17078786
• Drappatz J, Wen PY.Chemotherapy and targeted molecular therapies for brain metastases.Expert Rev Neurother 2006 Oct;6(10):1465-79.
  17078787
• Groves MD, Puduvalli VK, Chang SM, Conrad CA, Gilbert MR, Tremont-Lukats IW, Liu TJ, Peterson P, Schiff D, Cloughesy TF, Wen PY, Greenberg H, Abrey LE, DeAngelis LM, Hess KR, Lamborn KR, Prados MD, Yung WK.A North American brain tumor consortium (NABTC 99
  17031561
• Jackman DM, Holmes AJ, Lindeman N, Wen PY, Kesari S, Borras AM, Bailey C, de Jong F, Jänne PA, Johnson BE.Response and resistance in a non-small-cell lung cancer patient with an epidermal growth factor receptor mutation and leptomeningeal metastases treat
  16983123
• Wen PY, Yung WK, Lamborn KR, Dahia PL, Wang Y, Peng B, Abrey LE, Raizer J, Cloughesy TF, Fink K, Gilbert M, Chang S, Junck L, Schiff D, Lieberman F, Fine HA, Mehta M, Robins HI, DeAngelis LM, Groves MD, Puduvalli VK, Levin V, Conrad C, Maher EA, Aldape K,
  16914578
• Cloughesy TF, Wen PY, Robins HI, Chang SM, Groves MD, Fink KL, Junck L, Schiff D, Abrey L, Gilbert MR, Lieberman F, Kuhn J, DeAngelis LM, Mehta M, Raizer JJ, Yung WK, Aldape K, Wright J, Lamborn KR, Prados MD.Phase II trial of tipifarnib in patients with
  16877733
• Doherty L, Gigas DC, Kesari S, Drappatz J, Kim R, Zimmerman J, Ostrowsky L, Wen PY.Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas.Neurology 2006 Jul 11;67(1):156-8.
  16832099
• Wen PY, Schiff D, Kesari S, Drappatz J, Gigas DC, Doherty L.Medical management of patients with brain tumors.J Neurooncol 2006 Jun 29.
  16807780
• Wen PY, Kesari S, Drappatz J.Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment.Expert Rev Anticancer Ther 2006 May;6(5):733-54.
  16759164
• Richardson PG, Briemberg H, Jagannath S, Wen PY, Barlogie B, Berenson J, Singhal S, Siegel DS, Irwin D, Schuster M, Srkalovic G, Alexanian R, Rajkumar SV, Limentani S, Alsina M, Orlowski RZ, Najarian K, Esseltine D, Anderson KC, Amato AA.Frequency, charac
  16754936
• Prados MD, Lamborn K, Yung WK, Jaeckle K, Robins HI, Mehta M, Fine HA, Wen PY, Cloughesy T, Chang S, Nicholas MK, Schiff D, Greenberg H, Junck L, Fink K, Hess K, Kuhn J,.A phase 2 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a
  16533878
• Reardon DA, Wen PY.Therapeutic advances in the treatment of glioblastoma: rationale and potential role of targeted agents.Oncologist 2006 Feb;11(2):152-64.
  16476836
• Kesari S, Ramakrishna N, Sauvageot C, Stiles CD, Wen PY.Targeted molecular therapy of malignant gliomas.Curr Oncol Rep 2006 Jan;8(1):58-70.
  16464405
• Shah GD, Kesari S, Xu R, Batchelor TT, O'Neill AM, Hochberg FH, Levy B, Bradshaw J, Wen PY.Comparison of linear and volumetric criteria in assessing tumor response in adult high-grade gliomas.Neuro-oncol 2006 Jan;8(1):38-46.
  16443946
• Norden AD, Wen PY, Kesari S.Brain metastases.Curr Opin Neurol 2005 Dec;18(6):654-61.
  16280676
• Kesari S, Ramakrishna N, Sauvageot C, Stiles CD, Wen PY.Targeted molecular therapy of malignant gliomas.Curr Neurol Neurosci Rep 2005 May;5(3):186-97.
  15865884