DF/HCC Program Affiliation

Gastrointestinal Malignancies
Angiogenesis, Invasion, and Metastasis

Research Abstract

My research focuses on 1) pancreatic cancer and 2) intestinal regeneration. We are characterizing factors modulating invasiveness and metastatic potential of pancreatic cancers. Tissue arrays containing resected human pancreatic cancers and a corresponding clinical outcomes database are being constructed to evaluate the clinical importance of specific factors that have been identified using in vitro and in vivo model systems. In addition, we are characterizing the mechanisms of action of intestinal epithelium-specific growth factors and the biology of tissue-engineered intestine.

Publications

• Duxbury MS, Ito H, Benoit E, Waseem T, Ashley SW, Whang EE.A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells.Cancer Res 2004 Jun 1;64(11):3987-93.
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• Duxbury MS, Ito H, Ashley SW, Whang EE.CEACAM6 cross-linking induces caveolin-1-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells.J Biol Chem 2004 May 28;279(22):23176-82.
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• Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE.CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells.Oncogene 2004 Jan 15;23(2):465-73.
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