DF/HCC Program Affiliation

Cancer Genetics
Gastrointestinal Malignancies
Lung Cancer, Co-Leader
Cancer Epidemiology
Reduction of Cancer Risk and Disparities

DF/HCC Associations

Institutional Representative for HSPH, Executive Committee
Deputy Associate Director, Planning and Evaluation, Executive Committee
Member, Center Scientific Council

Research Abstract

Dr. Christiani's major research focus is Molecular Epidemiology of cancer. At MGH and HSPH he has led studies of genetic susceptibility to lung cancer as well as esophageal cancer. Recently, his work has expanded to the pharmacogenomics of treatment outcomes in lung and esophageal malignancies. He is investigating biologic markers of PAH and arsenic exposure for population studies. He also collaborates with international scientists on the molecular epidemiology of arsenic-induced bladder and skin cancer, and petrochemical exposures and brain neoplasms and leukemia in children. Finally, Dr. Christiani collaborates with faculty in the social and behavioral sciences on cancer prevention in the workplace and the community.

Publications

• Bajwa EK, Boyce PD, Januzzi JL, Gong MN, Thompson BT, Christiani DC.Biomarker evidence of myocardial cell injury is associated with mortality in acute respiratory distress syndrome.Crit Care Med 2007 Nov;35(11):2484-90.
  18084839
• McCarty KM, Smith TJ, Zhou W, Gonzalez E, Quamruzzaman Q, Rahman M, Mahiuddin G, Ryan L, Su L, Christiani DC.Polymorphisms in XPD (Asp312Asn and Lys751Gln) genes, sunburn and arsenic related skin lesions.Carcinogenesis 2007 Apr 29.
  17470448
• McCarty KM, Chen YC, Quamruzzaman Q, Rahman M, Mahiuddin G, Hsueh YM, Su L, Smith T, Ryan L, Christiani DC.Arsenic methylation, GSTT1, GSTM1, GSTP1 polymorphisms, and skin lesions.Environ Health Perspect 2007 Mar;115(3):341-5.
  17431481
• Christiani DC, Pao W, DeMartini JC, Linnoila RI, Malkinson AM, Onn A, Politi KA, Sharp M, Wong KK, Kim K.BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models.J Thorac Oncol 2006 Nov;1(9 Suppl):S2-7.
  17409996
• Breton CV, Zhou W, Kile ML, Houseman EA, Quamruzzaman Q, Rahman M, Mahiuddin G, Christiani DC.Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes.Carcinogenesis 2007 Mar 20.
  17374727
• Zhang H, Hang J, Wang X, Zhou W, Sun B, Dai H, Su L, Christiani DC.TNF Polymorphisms Modify Endotoxin Exposure Associated Longitudinal Lung Function Decline.Occup Environ Med 2007 Mar 1.
  17332138
• Zhai R, Gong MN, Zhou W, Thompson TB, Kraft P, Su L, Christiani DC.Genotypes and haplotypes of VEGF gene are associated with higher ARDS Mortality and lower VEGF plasma levels.Thorax 2007 Feb 8.
  17289863
• McCarty KM, Ryan L, Houseman EA, Williams PL, Miller DP, Quamruzzaman Q, Rahman M, Mahiuddin G, Smith T, Gonzalez E, Su L, Christiani DC.A case-control study of GST polymorphisms and arsenic related skin lesions.Environ Health 2007;6:5.
  17284320
• Yu CL, Wang SF, Pan PC, Wu MT, Ho CK, Smith TJ, Li Y, Pothier L, Christiani DC,.Residential exposure to petrochemicals and the risk of leukemia: using geographic information system tools to estimate individual-level residential exposure.Am J Epidemiol 200
  16754633
• Zhou W, Park S, Liu G, Miller DP, Wang LI, Pothier L, Wain JC, Lynch TJ, Giovannucci E, Christiani DC.Dietary iron, zinc, and calcium and the risk of lung cancer.Epidemiology 2005 Nov;16(6):772-9.
  16222167
• Zhou W, Suk R, Liu G, Park S, Neuberg DS, Wain JC, Lynch TJ, Giovannucci E, Christiani DC.Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patients.Cancer Epidemiol Biomarkers Prev 2005 Oct;14(10):2303-9.
  16214909
• Thurston SW, Liu G, Miller DP, Christiani DC.Modeling lung cancer risk in case-control studies using a new dose metric of smoking.Cancer Epidemiol Biomarkers Prev 2005 Oct;14(10):2296-302.
  16214908
• Suk R, Gurubhagavatula S, Park S, Zhou W, Su L, Lynch TJ, Wain JC, Neuberg D, Liu G, Christiani DC.Polymorphisms in ERCC1 and grade 3 or 4 toxicity in non-small cell lung cancer patients.Clin Cancer Res 2005 Feb 15;11(4):1534-8.
  15746057
• Zhou W, Liu G, Park S, Wang Z, Wain JC, Lynch TJ, Su L, Christiani DC.Gene-smoking interaction associations for the ERCC1 polymorphisms in the risk of lung cancer.Cancer Epidemiol Biomarkers Prev 2005 Feb;14(2):491-6.
  15734977
• Liu G, Zhou W, Wang LI, Park S, Miller DP, Xu LL, Wain JC, Lynch TJ, Su L, Christiani DC.MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinoma.Cancer Lett 2004 Oct 8;214(1):69-79.
  15331175
• Zhou W, Gurubhagavatula S, Liu G, Park S, Neuberg DS, Wain JC, Lynch TJ, Su L, Christiani DC.Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based c
  15297394
• Gurubhagavatula S, Liu G, Park S, Zhou W, Su L, Wain JC, Lynch TJ, Neuberg DS, Christiani DC.XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy.J Clin Oncol 2004 Ju
  15173214
• Zhao X, Li C, Paez JG, Chin K, Jänne PA, Chen TH, Girard L, Minna J, Christiani D, Leo C, Gray JW, Sellers WR, Meyerson M.An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays.Cancer Res
  15126342
• Kim JY, Mukherjee S, Ngo LC, Christiani DC.Urinary 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative DNA damage in workers exposed to fine particulates.Environ Health Perspect 2004 May;112(6):666-71.
  15121508
• Jänne PA, Li C, Zhao X, Girard L, Chen TH, Minna J, Christiani DC, Johnson BE, Meyerson M.High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines.Oncogene 2004 Apr 8;23(15):271
  15048096
• Miller DP, Neuberg D, de Vivo I, Wain JC, Lynch TJ, Su L, Christiani DC.Smoking and the risk of lung cancer: susceptibility with GSTP1 polymorphisms.Epidemiology 2003 Sep;14(5):545-51.
  14501269
• Zhou W, Liu G, Miller DP, Thurston SW, Xu LL, Wain JC, Lynch TJ, Su L, Christiani DC.Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk.Cancer Epidemiol Biomarkers Prev 2003 Apr;12(4):359-65.
  12692111