DF/HCC Program Affiliation

Cancer Genetics
Gastrointestinal Malignancies
Lung Cancer, Co-Leader
Cancer Epidemiology
Reduction of Cancer Risk and Disparities

DF/HCC Associations

Institutional Representative for HSPH, Executive Committee
Deputy Associate Director, Planning and Evaluation, Executive Committee
Member, Center Scientific Council

Research Abstract

Dr. Christiani's major research focus is Molecular Epidemiology of cancer. At MGH and HSPH he has led studies of genetic susceptibility to lung cancer as well as esophageal cancer. Recently, his work has expanded to the pharmacogenomics of treatment outcomes in lung and esophageal malignancies. He is investigating biologic markers of PAH and arsenic exposure for population studies. He also collaborates with international scientists on the molecular epidemiology of arsenic-induced bladder and skin cancer, and petrochemical exposures and brain neoplasms and leukemia in children. Finally, Dr. Christiani collaborates with faculty in the social and behavioral sciences on cancer prevention in the workplace and the community.

Publications

• Bajwa EK, Boyce PD, Januzzi JL, Gong MN, Thompson BT, Christiani DC.Biomarker evidence of myocardial cell injury is associated with mortality in acute respiratory distress syndrome.Crit Care Med 2007 Nov;35(11):2484-90.
  18084839
• McCarty KM, Smith TJ, Zhou W, Gonzalez E, Quamruzzaman Q, Rahman M, Mahiuddin G, Ryan L, Su L, Christiani DC.Polymorphisms in XPD (Asp312Asn and Lys751Gln) genes, sunburn and arsenic related skin lesions.Carcinogenesis 2007 Apr 29.
  17470448
• McCarty KM, Chen YC, Quamruzzaman Q, Rahman M, Mahiuddin G, Hsueh YM, Su L, Smith T, Ryan L, Christiani DC.Arsenic methylation, GSTT1, GSTM1, GSTP1 polymorphisms, and skin lesions.Environ Health Perspect 2007 Mar;115(3):341-5.
  17431481
• Christiani DC, Pao W, DeMartini JC, Linnoila RI, Malkinson AM, Onn A, Politi KA, Sharp M, Wong KK, Kim K.BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models.J Thorac Oncol 2006 Nov;1(9 Suppl):S2-7.
  17409996
• Breton CV, Zhou W, Kile ML, Houseman EA, Quamruzzaman Q, Rahman M, Mahiuddin G, Christiani DC.Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes.Carcinogenesis 2007 Mar 20.
  17374727
• Zhang H, Hang J, Wang X, Zhou W, Sun B, Dai H, Su L, Christiani DC.TNF Polymorphisms Modify Endotoxin Exposure Associated Longitudinal Lung Function Decline.Occup Environ Med 2007 Mar 1.
  17332138
• Zhai R, Gong MN, Zhou W, Thompson TB, Kraft P, Su L, Christiani DC.Genotypes and haplotypes of VEGF gene are associated with higher ARDS Mortality and lower VEGF plasma levels.Thorax 2007 Feb 8.
  17289863
• McCarty KM, Ryan L, Houseman EA, Williams PL, Miller DP, Quamruzzaman Q, Rahman M, Mahiuddin G, Smith T, Gonzalez E, Su L, Christiani DC.A case-control study of GST polymorphisms and arsenic related skin lesions.Environ Health 2007;6:5.
  17284320
• Yu CL, Wang SF, Pan PC, Wu MT, Ho CK, Smith TJ, Li Y, Pothier L, Christiani DC,.Residential exposure to petrochemicals and the risk of leukemia: using geographic information system tools to estimate individual-level residential exposure.Am J Epidemiol 200
  16754633
• Zhou W, Park S, Liu G, Miller DP, Wang LI, Pothier L, Wain JC, Lynch TJ, Giovannucci E, Christiani DC.Dietary iron, zinc, and calcium and the risk of lung cancer.Epidemiology 2005 Nov;16(6):772-9.
  16222167
• Thurston SW, Liu G, Miller DP, Christiani DC.Modeling lung cancer risk in case-control studies using a new dose metric of smoking.Cancer Epidemiol Biomarkers Prev 2005 Oct;14(10):2296-302.
  16214908
• Zhou W, Suk R, Liu G, Park S, Neuberg DS, Wain JC, Lynch TJ, Giovannucci E, Christiani DC.Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patients.Cancer Epidemiol Biomarkers Prev 2005 Oct;14(10):2303-9.
  16214909
• Suk R, Gurubhagavatula S, Park S, Zhou W, Su L, Lynch TJ, Wain JC, Neuberg D, Liu G, Christiani DC.Polymorphisms in ERCC1 and grade 3 or 4 toxicity in non-small cell lung cancer patients.Clin Cancer Res 2005 Feb 15;11(4):1534-8.
  15746057
• Zhou W, Liu G, Park S, Wang Z, Wain JC, Lynch TJ, Su L, Christiani DC.Gene-smoking interaction associations for the ERCC1 polymorphisms in the risk of lung cancer.Cancer Epidemiol Biomarkers Prev 2005 Feb;14(2):491-6.
  15734977
• Liu G, Zhou W, Wang LI, Park S, Miller DP, Xu LL, Wain JC, Lynch TJ, Su L, Christiani DC.MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinoma.Cancer Lett 2004 Oct 8;214(1):69-79.
  15331175
• Zhou W, Gurubhagavatula S, Liu G, Park S, Neuberg DS, Wain JC, Lynch TJ, Su L, Christiani DC.Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based c
  15297394
• Gurubhagavatula S, Liu G, Park S, Zhou W, Su L, Wain JC, Lynch TJ, Neuberg DS, Christiani DC.XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy.J Clin Oncol 2004 Ju
  15173214
• Zhao X, Li C, Paez JG, Chin K, Jänne PA, Chen TH, Girard L, Minna J, Christiani D, Leo C, Gray JW, Sellers WR, Meyerson M.An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays.Cancer Res
  15126342
• Kim JY, Mukherjee S, Ngo LC, Christiani DC.Urinary 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative DNA damage in workers exposed to fine particulates.Environ Health Perspect 2004 May;112(6):666-71.
  15121508
• Jänne PA, Li C, Zhao X, Girard L, Chen TH, Minna J, Christiani DC, Johnson BE, Meyerson M.High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines.Oncogene 2004 Apr 8;23(15):271
  15048096
• Miller DP, Neuberg D, de Vivo I, Wain JC, Lynch TJ, Su L, Christiani DC.Smoking and the risk of lung cancer: susceptibility with GSTP1 polymorphisms.Epidemiology 2003 Sep;14(5):545-51.
  14501269
• Zhou W, Liu G, Miller DP, Thurston SW, Xu LL, Wain JC, Lynch TJ, Su L, Christiani DC.Polymorphisms in the DNA repair genes XRCC1 and ERCC2, smoking, and lung cancer risk.Cancer Epidemiol Biomarkers Prev 2003 Apr;12(4):359-65.
  12692111
• Liu CY, Hsu YH, Pan PC, Wu MT, Ho CK, Su L, Xu X, Li Y, Christiani DC.Maternal and offspring genetic variants of AKR1C3 and the risk of childhood leukemia.Carcinogenesis 2008 Mar 13.
  18339682
• Heist RS, Zhai R, Liu G, Zhou W, Lin X, Su L, Asomaning K, Lynch TJ, Wain JC, Christiani DC.VEGF polymorphisms and survival in early-stage non-small-cell lung cancer.J Clin Oncol 2008 Feb 20;26(6):856-62.
  18281657
• Zhai R, Liu G, Zhou W, Su L, Heist RS, Lynch TJ, Wain JC, Asomaning K, Lin X, Christiani DC.Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer.Clin Cancer Res 2008 Jan 15;14(2):612-7.
  18223238
• Wheatley-Price P, Asomaning K, Reid A, Zhai R, Su L, Zhou W, Zhu A, Ryan DP, Christiani DC, Liu G.Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma.Cancer 2008 Mar 1;112(5)
  18205184
• Bradbury PA, Heist RS, Kulke MH, Zhou W, Marshall AL, Miller DP, Su L, Park S, Temel J, Fidias P, Sequist L, Lynch TJ, Wain JC, Shepherd FA, Christiani DC, Liu G.A rapid outcomes ascertainment system improves the quality of prognostic and pharmacogenetic
  18199725
• Asomaning K, Miller DP, Liu G, Wain JC, Lynch TJ, Su L, Christiani DC.Second hand smoke, age of exposure and lung cancer risk.Lung Cancer 2008 Jan 7.
  18191495
• Harezlak J,Wu MC,Wang M,Schwartzman A,Christiani DC,Lin X.Biomarker discovery for arsenic exposure using functional data. Analysis and feature learning of mass spectrometry proteomic data.J Proteome Res 2008 Jan;7(1):217-24.
  18173220
• Breton CV, Kile ML, Catalano PJ, Hoffman E, Quamruzzaman Q, Rahman M, Mahiuddin G, Christiani DC.GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures study.Environ Health 2007;6:39.
  18053222
• Liu G, Wheatley-Price P, Zhou W, Park S, Heist RS, Asomaning K, Wain JC, Lynch TJ, Su L, Christiani DC.Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk.Int J Cancer 2007 Oct 23.
  17957785
• Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC
  17676035
• Sholl LM, John Iafrate A, Chou YP, Wu MT, Goan YG, Su L, Huang YT, Christiani DC, Chirieac LR.Validation of chromogenic in situ hybridization for detection of EGFR copy number amplification in nonsmall cell lung carcinoma.Mod Pathol 2007 Oct;20(10):1028-3
  17673923
• Harezlak J,Wang M,Christiani D,Lin X.Quantitative quality-assessment techniques to compare fractionation and depletion methods in SELDI-TOF mass spectrometry experiments.Bioinformatics 2007 Sep 15;23(18):2441-8.
  17626063
• Heist RS, Zhou W, Chirieac LR, Cogan-Drew T, Liu G, Su L, Neuberg D, Lynch TJ, Wain JC, Christiani DC.MDM2 polymorphism, survival, and histology in early-stage non-small-cell lung cancer.J Clin Oncol 2007 Jun 1;25(16):2243-7.
  17538168
• Bajwa EK, Yu CL, Gong MN, Thompson BT, Christiani DC.Pre-B-cell colony-enhancing factor gene polymorphisms and risk of acute respiratory distress syndrome*.Crit Care Med 2007 Mar 19.
  17414088
• Liu G, Gurubhagavatula S, Zhou W, Wang Z, Yeap BY, Asomaning K, Su L, Heist R, Lynch TJ, Christiani DC.Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib.Pharmacogenomics J 20
  17375033
• McMahon PM, Christiani DC.Computed tomography screening for lung cancer.BMJ 2007 Feb 10;334(7588):271.
  17289689
• Zhou W, Heist RS, Liu G, Asomaning K, Neuberg DS, Hollis BW, Wain JC, Lynch TJ, Giovannucci E, Su L, Christiani DC.Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients.J Clin Oncol 2007 Feb 10;25(5):47
  17290055
• Liu G, Zhou W, Yeap BY, Su L, Wain JC, Poneros JM, Nishioka NS, Lynch TJ, Christiani DC.XRCC1 and XPD Polymorphisms and Esophageal Adenocarcinoma Risk.Carcinogenesis 2007 Jan 29.
  17264068
• Zhai R, Zhou W, Gong MN, Thompson BT, Su L, Yu C, Kraft P, Christiani DC.Inhibitor kappaB-alpha haplotype GTC is associated with susceptibility to acute respiratory distress syndrome in Caucasians.Crit Care Med 2007 Mar;35(3):893-8.
  17235259
• Lamontagne AD, Christiani DC.Prevention of work-related cancers.New Solut 2002;12(2):137-56.
  17208764
• Zhou W, Heist RS, Liu G, Asomaning K, Miller DP, Neuberg DS, Wain JC, Lynch TJ, Christiani DC.Second hand smoke exposure and survival in early-stage non-small-cell lung cancer patients.Clin Cancer Res 2006 Dec 1;12(23):7187-93.
  17145845
• Gong MN, Zhou W, Williams PL, Thompson BT, Pothier L, Christiani DC.Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome.Crit Care Med 2007 Jan;35(1):48-56.
  17133182
• Zhou W, Heist RS, Liu G, Neuberg DS, Asomaning K, Su L, Wain JC, Lynch TJ, Giovannucci E, Christiani DC.Polymorphisms of vitamin d receptor and survival in early-stage non-small cell lung cancer patients.Cancer Epidemiol Biomarkers Prev 2006 Nov;15(11):22
  17119052
• Heist RS, Marshall AL, Liu G, Zhou W, Su L, Neuberg D, Lynch TJ, Wain J, Christiani DC.Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer.Clin Cancer Res 2006 Sep 15;12(18):5448-53.
  17000679
• Fang SC, Eisen EA, Dai H, Zhang H, Hang J, Wang X, Christiani DC.Cancer mortality among textile workers in Shanghai, China: a preliminary study.J Occup Environ Med 2006 Sep;48(9):955-8.
  16966963
• Miller DP, Asomaning K, Liu G, Wain JC, Lynch TJ, Neuberg D, Su L, Christiani DC.An association between glutathione S-transferase P1 gene polymorphism and younger age at onset of lung carcinoma.Cancer 2006 Oct 1;107(7):1570-7.
  16933328
• Zhou W, Heist RS, Liu G, Park S, Neuberg DS, Asomaning K, Wain JC, Lynch TJ, Christiani DC.Smoking cessation before diagnosis and survival in early stage non-small cell lung cancer patients.Lung Cancer 2006 Jun 28.
  16814423
• Breton CV, Houseman EA, Kile ML, Quamruzzaman Q, Rahman M, Mahiuddin G, Christiani DC.Gender-specific protective effect of hemoglobin on arsenic-induced skin lesions.Cancer Epidemiol Biomarkers Prev 2006 May;15(5):902-7.
  16702368
• Wang X, Yano E, Wang Z, Wang M, Christiani DC.Adverse effects of asbestos exposure and smoking on lung function.Am J Ind Med 2006 May;49(5):337-42.
  16570255
• Christiani DC.Genetic susceptibility to lung cancer.J Clin Oncol 2006 Apr 10;24(11):1651-2.
  16549817
• Yu CL, Wang SF, Pan PC, Wu MT, Ho CK, Smith TJ, Li Y, Pothier LJ, Christiani DC.No association between residential exposure to petrochemicals and brain tumor risk.Cancer Epidemiol Biomarkers Prev 2005 Dec;14(12):3007-9.
  16365027
• Su L, Zhou W, Asomaning K, Lin X, Wain JC, Lynch TJ, Liu G, Christiani DC.Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer.Carcinogenesis 2006 May;27(5):1024-1029.
  16311244
• Kile ML, Houseman EA, Rodrigues E, Smith TJ, Quamruzzaman Q, Rahman M, Mahiuddin G, Su L, Christiani DC.Toenail arsenic concentrations, GSTT1 gene polymorphisms, and arsenic exposure from drinking water.Cancer Epidemiol Biomarkers Prev 2005 Oct;14(10):241
  16214926
• Liu G, Zhou W, Christiani DC.Molecular epidemiology of non-small cell lung cancer.Semin Respir Crit Care Med 2005 Jun;26(3):265-72.
  16052427
• Zhao X, Weir BA, LaFramboise T, Lin M, Beroukhim R, Garraway L, Beheshti J, Lee JC, Naoki K, Richards WG, Sugarbaker D, Chen F, Rubin MA, Jänne PA, Girard L, Minna J, Christiani D, Li C, Sellers WR, Meyerson M.Homozygous deletions and chromosome amplifica
  15994928
• Várkonyi A, Kelsey K, Semey K, Bodell WJ, Lévay G, Mark E, Wain JC, Christiani DC, Wiencke JK.Polyphenol associated-DNA adducts in lung and blood mononuclear cells from lung cancer patients.Cancer Lett 2006 May 8;236(1):24-31.
  15967573
• Chen YC, Su HJ, Guo YL, Houseman EA, Christiani DC.Interaction between environmental tobacco smoke and arsenic methylation ability on the risk of bladder cancer.Cancer Causes Control 2005 Mar;16(2):75-81.
  15868449
• Wang LI, Giovannucci EL, Hunter D, Neuberg D, Su L, Christiani DC.Dietary intake of Cruciferous vegetables, Glutathione S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population.Cancer Causes Control 2004 Dec;15(10):977-85.
  15801482
• Kim JY, Hecht SS, Mukherjee S, Carmella SG, Rodrigues EG, Christiani DC.A urinary metabolite of phenanthrene as a biomarker of polycyclic aromatic hydrocarbon metabolic activation in workers exposed to residual oil fly ash.Cancer Epidemiol Biomarkers Prev
  15767350
• Su L, Zhou W, Park S, Wain JC, Lynch TJ, Liu G, Christiani DC.Matrix metalloproteinase-1 promoter polymorphism and lung cancer risk.Cancer Epidemiol Biomarkers Prev 2005 Mar;14(3):567-70.
  15767330
• Zellos L, Christiani DC.Epidemiology, biologic behavior, and natural history of mesothelioma.Thorac Surg Clin 2004 Nov;14(4):469-77, viii.
  15559053
• Liu G, Zhou W, Park S, Wang LI, Miller DP, Wain JC, Lynch TJ, Su L, Christiani DC.The SOD2 Val/Val genotype enhances the risk of nonsmall cell lung carcinoma by p53 and XRCC1 polymorphisms.Cancer 2004 11 8.
  15534883
• Wang LI, Neuberg D, Christiani DC.Asbestos exposure, manganese superoxide dismutase (MnSOD) genotype, and lung cancer risk.J Occup Environ Med 2004 Jun;46(6):556-64.
  15213518
• Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA.Activating mutations in the epidermal growth factor receptor underlying responsiveness
  15118073
• Lange JH, Mastrangelo G, Fedeli U, Rylander R, Christiani DC.A benefit of reducing lung cancer incidence in women occupationally exposed to cotton textile dust.Am J Ind Med 2004 Apr;45(4):388-9; author reply 390.
  15029574
• Mukherjee S, Palmer LJ, Kim JY, Aeschliman DB, Houk RS, Woodin MA, Christiani DC.Smoking status and occupational exposure affects oxidative DNA injury in boilermakers exposed to metal fume and residual oil fly ash.Cancer Epidemiol Biomarkers Prev 2004 Mar
  15006923
• Gong MN, Sai Y, Zhou W, Thompson BT, Xu LL, Christiani DC.Genotyping patients with recent blood transfusions.Epidemiology 2003 Nov;14(6):744-7.
  14569193
• Huang CI, Neuberg D, Johnson BE, Wei JY, Christiani DC.Expression of bcl-2 protein is associated with shorter survival in nonsmall cell lung carcinoma.Cancer 2003 Jul 1;98(1):135-43.
  12833466
• LaMontagne AD, Youngstrom RA, Lewiton M, Stoddard AM, Perry MJ, Klar JM, Christiani DC, Sorensen G.An exposure prevention rating method for intervention needs assessment and effectiveness evaluation.Appl Occup Environ Hyg 2003 Jul;18(7):523-34.
  12791549
• Su L, Sai Y, Fan R, Thurston SW, Miller DP, Zhou W, Wain JC, Lynch TJ, Liu G, Christiani DC.P53 (codon 72) and P21 (codon 31) polymorphisms alter in vivo mRNA expression of p21.Lung Cancer 2003 Jun;40(3):259-66.
  12781424
• Sorensen G, Stoddard AM, LaMontagne AD, Emmons K, Hunt MK, Youngstrom R, McLellan D, Christiani DC.A comprehensive worksite cancer prevention intervention: behavior change results from a randomized controlled trial (United States).J Public Health Policy 2
  12760241
• Miller DP, De Vivo I, Neuberg D, Wain JC, Lynch TJ, Su L, Christiani DC.Association between self-reported environmental tobacco smoke exposure and lung cancer: modification by GSTP1 polymorphism.Int J Cancer 2003 May 10;104(6):758-63.
  12640684
• Su L, Liu G, Zhou W, Xu LL, Miller DP, Park S, Lynch TJ, Wain JC, Christiani DC.No association between the p21 codon 31 serine-arginine polymorphism and lung cancer risk.Cancer Epidemiol Biomarkers Prev 2003 Feb;12(2):174-5.
  12582031
• Xu LL, Liu G, Miller DP, Zhou W, Lynch TJ, Wain JC, Su L, Christiani DC.Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in Caucasians.Cancer Epidemiol Biomarkers Prev 2002 Dec;11(12):1555-9.
  12496043
• Sorensen G, Stoddard AM, LaMontagne AD, Emmons K, Hunt MK, Youngstrom R, McLellan D, Christiani DC.A comprehensive worksite cancer prevention intervention: behavior change results from a randomized controlled trial (United States).Cancer Causes Control 20
  12195637
• Miller DP, Liu G, De Vivo I, Lynch TJ, Wain JC, Su L, Christiani DC.Combinations of the variant genotypes of GSTP1, GSTM1, and p53 are associated with an increased lung cancer risk.Cancer Res 2002 May 15;62(10):2819-23.
  12019159
• Zhou W, Liu G, Miller DP, Thurston SW, Xu LL, Wain JC, Lynch TJ, Su L, Christiani DC.Gene-environment interaction for the ERCC2 polymorphisms and cumulative cigarette smoking exposure in lung cancer.Cancer Res 2002 Mar 1;62(5):1377-81.
  11888908
• Zhou W, Liu G, Thurston SW, Xu LL, Miller DP, Wain JC, Lynch TJ, Su L, Christiani DC.Genetic polymorphisms in N-acetyltransferase-2 and microsomal epoxide hydrolase, cumulative cigarette smoking, and lung cancer.Cancer Epidemiol Biomarkers Prev 2002 Jan;1
  11815396
• Liu G, Miller DP, Zhou W, Thurston SW, Fan R, Xu LL, Lynch TJ, Wain JC, Su L, Christiani DC.Differential association of the codon 72 p53 and GSTM1 polymorphisms on histological subtype of non-small cell lung carcinoma.Cancer Res 2001 Dec 15;61(24):8718-22
  11751390
• Wang LI, Miller DP, Sai Y, Liu G, Su L, Wain JC, Lynch TJ, Christiani DC.Manganese superoxide dismutase alanine-to-valine polymorphism at codon 16 and lung cancer risk.J Natl Cancer Inst 2001 Dec 5;93(23):1818-21.
  11734599
• Zhou W, Thurston SW, Liu G, Xu LL, Miller DP, Wain JC, Lynch TJ, Su L, Christiani DC.The interaction between microsomal epoxide hydrolase polymorphisms and cumulative cigarette smoking in different histological subtypes of lung cancer.Cancer Epidemiol Bio
  11352855
• Xu LL, Wain JC, Miller DP, Thurston SW, Su L, Lynch TJ, Christiani DC.The NAD(P)H:quinone oxidoreductase 1 gene polymorphism and lung cancer: differential susceptibility based on smoking behavior.Cancer Epidemiol Biomarkers Prev 2001 Apr;10(4):303-9.
  11319169
• Kim DH, Nelson HH, Wiencke JK, Christiani DC, Wain JC, Mark EJ, Kelsey KT.Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer.Oncogene 2001 Mar 29;20(14):1765-70.
  11313923
• Kim DH, Nelson HH, Wiencke JK, Zheng S, Christiani DC, Wain JC, Mark EJ, Kelsey KT.p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer.Cancer Res 2001 Apr 15;61(8):3419-24.
  11309302
• Hirao T, Nelson HH, Ashok TD, Wain JC, Mark EJ, Christiani DC, Wiencke JK, Kelsey KT.Tobacco smoke-induced DNA damage and an early age of smoking initiation induce chromosome loss at 3p21 in lung cancer.Cancer Res 2001 Jan 15;61(2):612-5.
  11212258
• Fan R, Wu MT, Miller D, Wain JC, Kelsey KT, Wiencke JK, Christiani DC.The p53 codon 72 polymorphism and lung cancer risk.Cancer Epidemiol Biomarkers Prev 2000 Oct;9(10):1037-42.
  11045785
• Christiani DC.Smoking and the molecular epidemiology of lung cancer.Clin Chest Med 2000 Mar;21(1):87-93, viii.
  10763091
• Nelson HH, Christiani DC, Wiencke JK, Mark EJ, Wain JC, Kelsey KT.k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis.Cancer Res 1999 Sep 15;59(18):4570-3.
  10493509
• Lee BW, Wain JC, Kelsey KT, Wiencke JK, Christiani DC.Association between diet and lung cancer location.Am J Respir Crit Care Med 1998 Oct;158(4):1197-203.
  9769282