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Stephen J. Elledge, PhD

Gregor Mendel Professor of Genetics and of Medicine, Department of Genetics, Harvard Medical School

Professor, Department of Medicine, Harvard Medical School

Contact Info

Stephen Elledge
Brigham And Women's Hospital
77 Avenue Louis Pasteur
Boston, MA, 02115
Mailstop: 158D
Phone not available.
selledge@genetics.med.harvard.edu

Assistant

Cynthia Hanes
Administrative Assistant
Genetics
Harvard Medical School
77 Avenue Louis Pasteur
Boston, MA, 02115
Phone: 617-525-4511
Fax: 617-525-4500
chanes@rics.bwh.harvard.edu

DF/HCC Program Affiliation

Cancer Cell Biology
Cancer Genetics

Research Abstract

I am interested in a number of areas relevant to cancer biology. I have had extensive experience in unraveling the signaling pathways involved in sensing and responding to DNA damage. This has involved both yeast and mammalian systems. We have performed work on the yeast Mec1, Mrc1, Rad53, Chk1, Dun1, Crt1, RNR1, RNR2, RNR3 and RNR4 genes as well as a number of cell cycle regulators including Cdc5 and the mitotic exit network genes Bub1, Bfa1 and Amn1. In mammals we have worked on the ATM, ATR,ATRIP, RPA, Rad17, Claspin, Chk1, Chk2,Cdc25 and p53 genes. I am continuing to explore new avenues in DNA damage signaling. In addiiton to our interests in DNA damage and cell cycle regulation in general, I have worked extensively in the past on Cdk regulation including Cdk2, cyclin A, cyclin F, and the p21 family of Cdk inhibitors, CKIs, including the Beckwith-Weidemann gene, p57. More recently our studies of cyclin and CKI metabolism led to the discovery of F-box proteins and the SCF pathway of regulated protein stability. Our more recent studies have focussed on development of genetic methods to over-express and knock-out mammalian genes using siRNA to perform genetic screens in mammalian cells.

Publications

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