DF/HCC Program Affiliation

Cancer Cell Biology
Cancer Genetics

Research Abstract

We use genomic systems biology to model
regulatory and enzymatic networks in mammalian and microbial cells. We develop technologies based on DNA-arrays, mass-spectrometry, automated microfluidics, polonies, and homologous recombination genome engineering. We have used these to discover genes affectng cell proliferation, alternative RNA splicing, and new regulatory sites involved in cell-cycle control and stress responses. We have developed integrated gene expression and functional genomics databases. For additional information see http://arep.med.harvard.edu.

Publications

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