DF/HCC Program Affiliation

Sarcoma
Cancer Genetics

Research Abstract

My research interests include the application of cytology and cytologic methods, including fine needle aspiration and Pap testing, to cancer diagnosis and treatment response. Particular interests include cervical cancer, mesothelioma, sarcoma, lung cancer, thyroid cancer, and prostate cancer. We have demonstrated the value of cytogenetics and molecular cytogenetics as adjuncts to diagnostic cytology. In collaboration with Dr. Jonathan Fletcher, we have also investigated the ability to use cytologic preparations to monitor treatment response and have developed a robust, cytology-based assay to measure tumor susceptibility to target-specific small molecule inhibitors. More recently, we have implemented the CellSearch instrument for enumerating circulating tumor cells and are embarking on collaborative studies to evaluate their clinical significance as well as their value in understanding the molecular mechanisms of metastasis.

Publications

• Chang BS, Yang T, Cibas ES, Fletcher JA.An in vitro cytologic assay for evaluation of the KIT signaling pathway in gastrointestinal stromal tumors.Mod Pathol 2007 May;20(5):579-83.
  17396139
• Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, Cronan JJ, Doubilet PM, Evans DB, Goellner JR, Hay ID, Hertzberg BS, Intenzo CM, Jeffrey RB, Langer JE, Larsen PR, Mandel SJ, Middleton WD, Reading CC, Sherman SI, Tessler FN.Management
  17146329
• Frates MC, Benson CB, Doubilet PM, Kunreuther E, Contreras M, Cibas ES, Orcutt J, Moore FD, Larsen PR, Marqusee E, Alexander EK.Prevalence and Distribution of Carcinoma in Patients with Solitary and Multiple Thyroid Nodules on Sonography.J Clin Endocrinol
  16835280
• Silverman SG, Gan YU, Mortele KJ, Tuncali K, Cibas ES.Renal masses in the adult patient: the role of percutaneous biopsy.Radiology 2006 Jul;240(1):6-22.
  16709793
• French CA, Alexander EK, Cibas ES, Nose V, Laguette J, Faquin W, Garber J, Moore F, Fletcher JA, Larsen PR, Kroll TG.Genetic and biological subgroups of low-stage follicular thyroid cancer.Am J Pathol 2003 Apr;162(4):1053-60.
  12651598