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Karen Cichowski, PhD

Associate Professor, Department of Medicine, Harvard Medical School

Associate Professor, Medicine/Genetics, Brigham And Women's Hospital

Associate Professor, Genetics, Brigham And Women's Hospital

Contact Info

Karen Cichowski
Brigham and Women's Hospital
77 Avenue Louis Pasteur
Boston, MA, 02115
Mailstop: 458D NRB
Phone: 617-525-4722
Fax: 617-525-4705


Tracy Dunn
Administrative Assistant
Department of Medicine, Division of Genetics
Brigham And Women's Hospital
77 Avenue Louis Pasteur
Boston, MA, 02115
Mailstop: Harvard New Research Building
Phone: 617-525-4743
Fax: 617-525-4705

DF/HCC Program Affiliation

Cancer Cell Biology

DF/HCC Associations

Chair, Center Scientific Council
Associate Director, Planning and Evaluation, Executive Committee

Research Abstract

The focus of my laboratory is to elucidate how deregulated cell signaling drives cancer. To achieve this we have been taking a multi-faceted approach; combining mouse modeling techniques with basic biochemical and cell biological studies. One of the most commonly deregulated signaling pathways in human cancer is the Ras pathway. Mutations can occur in Ras itself, upstream regulators, or downstream effectors. Therefore we have been focusing on how this pathway promotes nervous system, lung, prostate, and breast cancers. We have also been using our mouse models and insight to develop novel therapies, several of which have been developed into clinical trials.


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