David E. Clapham, M.D. Ph.D.

Aldo R. Castaneda Professor of Cardiovascular, Department of Neurobiology, Harvard Medical School

Aldo R. Castaneda Professor of Cardiovascular, Department of Pediatrics, Harvard Medical School

Aldo R. Castaneda Professor of Cardiovascular Research, Howard Hughes Medical Institute, Children's Hospital Boston

Contact Info

David Clapham
Harvard Medical School
320 Longwood Avenue
Boston, MA, 02115
Mailstop: Enders 1309
Phone: 617-919-2680
Fax: 617-731-0787
dclapham@enders.tch.harvard.edu

Assistant

Michelle Merry
Administrative Assistant
Howard Hughes Medical Institute
Children's Hospital Boston
320 Longwood Avenue
Boston, MA, 02115
Phone: 617-919-2680
Fax: 617-731-0787
memerry@enders.tch.harvrd.edu

DF/HCC Program Affiliation

Lymphoma and Myeloma
Cancer Cell Biology

Research Abstract

Not Available.

Publications

Xu H, Delling M, Jun JC, Clapham DE.Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels.Nat Neurosci 2006 May;9(5):628-635.
16617338
Ramsey IS, Moran MM, Chong JA, Clapham DE.A voltage-gated proton-selective channel lacking the pore domain.Nature 2006 Apr 27;440(7088):1213-6.
16554753
Kirichok Y, Navarro B, Clapham DE.Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel.Nature 2006 Feb 9;439(7077):737-40.
16467839
Ramsey IS, Delling M, Clapham DE.An introduction to trp channels.Annu Rev Physiol 2006;68:619-47.
16460286
Oancea E, Wolfe JT, Clapham DE.Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow.Circ Res 2006 Feb 3;98(2):245-53.
16357306
Xu H, Blair NT, Clapham DE.Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism.J Neurosci 2005 Sep 28;25(39):8924-37.
16192383
Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE.Rapid vesicular translocation and insertion of TRP channels.Nat Cell Biol 2004 Aug;6(8):709-20.
15258588
Kirichok Y, Krapivinsky G, Clapham DE.The mitochondrial calcium uniporter is a highly selective ion channel.Nature 2004 Jan 22;427(6972):360-4.
14737170
Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL, Babcock DF.CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm.Proc Natl Acad Sci U S A 2003 Dec 9;100(25):14864-8.
14657352
Clapham DE.TRP channels as cellular sensors.Nature 2003 Dec 4;426(6966):517-24.
14654832
Greka A, Navarro B, Oancea E, Duggan A, Clapham DE.TRPC5 is a regulator of hippocampal neurite length and growth cone morphology.Nat Neurosci 2003 Aug;6(8):837-45.
12858178
Clapham DE.Sorting out MIC, TRP, and CRAC ion channels.J Gen Physiol 2002 Aug;120(2):217-20.
12149282
Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE.TRPV3 is a calcium-permeable temperature-sensitive cation channel.Nature 2002 Jul 11;418(6894):181-6.
12077604
Runnels LW, Yue L, Clapham DE.The TRPM7 channel is inactivated by PIP(2) hydrolysis.Nat Cell Biol 2002 May;4(5):329-36.
11941371
Ren D, Navarro B, Xu H, Yue L, Shi Q, Clapham DE.A prokaryotic voltage-gated sodium channel.Science 2001 Dec 14;294(5550):2372-5.
11743207
Quill TA, Ren D, Clapham DE, Garbers DL.A voltage-gated ion channel expressed specifically in spermatozoa.Proc Natl Acad Sci U S A 2001 Oct 23;98(22):12527-31.
11675491
Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE.A sperm ion channel required for sperm motility and male fertility.Nature 2001 Oct 11;413(6856):603-9.
11595941
Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE.TRPC1 and TRPC5 form a novel cation channel in mammalian brain.Neuron 2001 Mar;29(3):645-55.
11301024
Yue L, Peng JB, Hediger MA, Clapham DE.CaT1 manifests the pore properties of the calcium-release-activated calcium channel.Nature 2001 Apr 5;410(6829):705-9.
11287959
Runnels LW, Yue L, Clapham DE.TRP-PLIK, a bifunctional protein with kinase and ion channel activities.Science 2001 Feb 9;291(5506):1043-7.
11161216

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DF/HCC Directory Login Update Member Profile Change Account Settings Applying for Membership Benefits Requirements Responsibilities	David E. Clapham, M.D. Ph.D. Aldo R. Castaneda Professor of Cardiovascular, Department of Neurobiology, Harvard Medical School Aldo R. Castaneda Professor of Cardiovascular, Department of Pediatrics, Harvard Medical School Aldo R. Castaneda Professor of Cardiovascular Research, Howard Hughes Medical Institute, Children's Hospital Boston Contact Info David Clapham Harvard Medical School 320 Longwood Avenue Boston, MA, 02115 Mailstop: Enders 1309 Phone: 617-919-2680 Fax: 617-731-0787 dclapham@enders.tch.harvard.edu Assistant Michelle Merry Administrative Assistant Howard Hughes Medical Institute Children's Hospital Boston 320 Longwood Avenue Boston, MA, 02115 Phone: 617-919-2680 Fax: 617-731-0787 memerry@enders.tch.harvrd.edu DF/HCC Program Affiliation Lymphoma and Myeloma Cancer Cell Biology Research Abstract Not Available. Publications Xu H, Delling M, Jun JC, Clapham DE.Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels.Nat Neurosci 2006 May;9(5):628-635. 16617338 Ramsey IS, Moran MM, Chong JA, Clapham DE.A voltage-gated proton-selective channel lacking the pore domain.Nature 2006 Apr 27;440(7088):1213-6. 16554753 Kirichok Y, Navarro B, Clapham DE.Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel.Nature 2006 Feb 9;439(7077):737-40. 16467839 Ramsey IS, Delling M, Clapham DE.An introduction to trp channels.Annu Rev Physiol 2006;68:619-47. 16460286 Oancea E, Wolfe JT, Clapham DE.Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow.Circ Res 2006 Feb 3;98(2):245-53. 16357306 Xu H, Blair NT, Clapham DE.Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism.J Neurosci 2005 Sep 28;25(39):8924-37. 16192383 Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE.Rapid vesicular translocation and insertion of TRP channels.Nat Cell Biol 2004 Aug;6(8):709-20. 15258588 Kirichok Y, Krapivinsky G, Clapham DE.The mitochondrial calcium uniporter is a highly selective ion channel.Nature 2004 Jan 22;427(6972):360-4. 14737170 Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL, Babcock DF.CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm.Proc Natl Acad Sci U S A 2003 Dec 9;100(25):14864-8. 14657352 Clapham DE.TRP channels as cellular sensors.Nature 2003 Dec 4;426(6966):517-24. 14654832 Greka A, Navarro B, Oancea E, Duggan A, Clapham DE.TRPC5 is a regulator of hippocampal neurite length and growth cone morphology.Nat Neurosci 2003 Aug;6(8):837-45. 12858178 Clapham DE.Sorting out MIC, TRP, and CRAC ion channels.J Gen Physiol 2002 Aug;120(2):217-20. 12149282 Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE.TRPV3 is a calcium-permeable temperature-sensitive cation channel.Nature 2002 Jul 11;418(6894):181-6. 12077604 Runnels LW, Yue L, Clapham DE.The TRPM7 channel is inactivated by PIP(2) hydrolysis.Nat Cell Biol 2002 May;4(5):329-36. 11941371 Ren D, Navarro B, Xu H, Yue L, Shi Q, Clapham DE.A prokaryotic voltage-gated sodium channel.Science 2001 Dec 14;294(5550):2372-5. 11743207 Quill TA, Ren D, Clapham DE, Garbers DL.A voltage-gated ion channel expressed specifically in spermatozoa.Proc Natl Acad Sci U S A 2001 Oct 23;98(22):12527-31. 11675491 Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE.A sperm ion channel required for sperm motility and male fertility.Nature 2001 Oct 11;413(6856):603-9. 11595941 Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE.TRPC1 and TRPC5 form a novel cation channel in mammalian brain.Neuron 2001 Mar;29(3):645-55. 11301024 Yue L, Peng JB, Hediger MA, Clapham DE.CaT1 manifests the pore properties of the calcium-release-activated calcium channel.Nature 2001 Apr 5;410(6829):705-9. 11287959 Runnels LW, Yue L, Clapham DE.TRP-PLIK, a bifunctional protein with kinase and ion channel activities.Science 2001 Feb 9;291(5506):1043-7. 11161216
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