• Home
  • News
  • Calendar
  • About DF/HCC
  • Membership
  • Visitor Center

David E. Clapham, MD, PhD

Aldo R. Castaneda Professor of Cardiovascular, Department of Neurobiology, Harvard Medical School

Aldo R. Castaneda Professor of Cardiovascular, Department of Pediatrics, Harvard Medical School

Aldo R. Castaneda Professor of Cardiovascular Research, Howard Hughes Medical Institute, Boston Children's Hospital

Contact Info

David Clapham
Harvard Medical School
320 Longwood Avenue
Boston, MA, 02115
Mailstop: Enders 1309
Phone: 617-919-2680
Fax: 617-731-0787
dclapham@enders.tch.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Cancer Cell Biology

Lab Website

clapham laboratory

Research Abstract

The Clapham laboratory discovers and elucidates the structure and function of ion channels, as well as their role in overall biology of the organism. Recently we identified ion channels in primary cilia that are linked to Hedgehog signaling, a target of cancer therapies. We employ patch clamp electrophysiology, advanced imaging, biochemistry, and genetic manipulation to identify the genes that encode ion channels and their associated proteins. We are currently investigating the following channels and transporters:
TRP channels (TRPC1,4,5; TRPV3, 4; TRPM6, TRPM7)
Voltage-gated proton channels (Hv1)
Mitochondrial channels (MCU and its subunits)
Mitochondrial transporters (Letm1)
Cilia channels (PKD and PKDL)
Osmosensitive chloride channels
Sperm-specific ion channels (CatSper, Slo3)

Publications

View All Publications