DF/HCC Program Affiliation

Cancer Epidemiology, Co-Leader
Gastrointestinal Malignancies
Prostate Cancer
Reduction of Cancer Risk and Disparities
Breast Cancer

DF/HCC Associations

Member, Center Scientific Council

Research Abstract

Major research activities include the identification of nutritional and hormonal determinants of cancer risk. A major focus has been the development of epidemiologic methods to measure dietary intake in large epidemiologic studies. These have been applied in three large cohorts totaling over 250,000 men and women: The Nurses' Health Study, Nurses' Health Study II, and Health Professionals Follow-up Study. In these studies plasma and DNA samples have been collected from nearly 100,000 participants, which allows the evaluation of hormonal and genetic hypotheses.

Publications

• Field AE, Willett WC, Lissner L, Colditz GA.Dietary fat and weight gain among women in the Nurses' Health Study.Obesity (Silver Spring) 2007 Apr;15(4):967-76.
  17426332
• Holmes MD, Powell IJ, Campos H, Stampfer MJ, Giovannucci EL, Willett WC.Validation of a food frequency questionnaire measurement of selected nutrients using biological markers in African-American men.Eur J Clin Nutr 2007 Feb 7.
  17299490
• Kim EH, Willett WC, Colditz GA, Hankinson SE, Stampfer MJ, Hunter DJ, Rosner B, Holmes MD.Dietary fat and risk of postmenopausal breast cancer in a 20-year follow-up.Am J Epidemiol 2006 Nov 15;164(10):990-7.
  16968865
• Eliassen AH, Colditz GA, Rosner B, Willett WC, Hankinson SE.Adult weight change and risk of postmenopausal breast cancer.JAMA 2006 Jul 12;296(2):193-201.
  16835425
• Baer HJ, Rich-Edwards JW, Colditz GA, Hunter DJ, Willett WC, Michels KB.Adult height, age at attained height, and incidence of breast cancer in premenopausal women.Int J Cancer 2006 Jul 5.
  16823843
• Michels KB, Xue F, Terry KL, Willett WC.Longitudinal study of birthweight and the incidence of breast cancer in adulthood.Carcinogenesis 2006 Jun 15.
  16777984
• Fung TT, Hu FB, McCullough ML, Newby PK, Willett WC, Holmes MD.Diet quality is associated with the risk of estrogen receptor-negative breast cancer in postmenopausal women.J Nutr 2006 Feb;136(2):466-72.
  16424129
• Beattie MS, Costantino JP, Cummings SR, Wickerham DL, Vogel VG, Dowsett M, Folkerd EJ, Willett WC, Wolmark N, Hankinson SE.Endogenous sex hormones, breast cancer risk, and tamoxifen response: an ancillary study in the NSABP Breast Cancer Prevention Trial
  16418513
• Baer HJ, Schnitt SJ, Connolly JL, Byrne C, Willett WC, Rosner B, Colditz GA.Early life factors and incidence of proliferative benign breast disease.Cancer Epidemiol Biomarkers Prev 2005 Dec;14(12):2889-97.
  16365006
• Michels KB, Rosner BA, Chumlea WC, Colditz GA, Willett WC.Preschool diet and adult risk of breast cancer.Int J Cancer 2005 Aug 10.
  16094624
• Zhang S, Hunter DJ, Hankinson SE, Giovannucci EL, Rosner BA, Colditz GA, Speizer FE, Willett WC.A prospective study of folate intake and the risk of breast cancer.JAMA 1999 May 5;281(17):1632-7.
  10235158
• Holmes MD, Hunter DJ, Colditz GA, Stampfer MJ, Hankinson SE, Speizer FE, Rosner B, Willett WC.Association of dietary intake of fat and fatty acids with risk of breast cancer.JAMA 1999 Mar 10;281(10):914-20.
  10078488
• Giovannucci E, Stampfer MJ, Colditz GA, Hunter DJ, Fuchs C, Rosner BA, Speizer FE, Willett WC.Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study.Ann Intern Med 1998 Oct 1;129(7):517-24.
  9758570