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Jeffrey W. Clark, MD

Associate Professor, Department of Medicine, Harvard Medical School

Medical Director, Cancer Center Protocol Office, Massachusetts General Hospital

Director of the Clinical Trials Core, Dana-Farber/Partners Cancer Care, Massachusetts General Hospital

Contact Info

Jeffrey Clark
Massachusetts General Hospital
55 Fruit St
Boston, MA, 02114
Mailstop: POB 234
Phone: 617-643-3415
Fax: 617-724-3166
jclark@partners.org

Assistant

Gwen White
MGH Cancer Center
Massachusetts General Hospital
55 Fruit St.
Boston, MA, 02114
Phone: 617-643-3415
Fax: 617-724-3166
gwhite6@partners.org

DF/HCC Program Affiliation

Gastrointestinal Malignancies
Translational Pharmacology and Early Therapeutic Trials

DF/HCC Associations

Medical Director, Clinical Trials Operations, Executive Committee
Director, Protocol Review and Monitoring System
Director, Clinical Research Support
Member, Clinical Science Coordinating Committee
Member, Center Scientific Council

Research Abstract

The major area of my research focus is in the evaluation of new agents and approaches in phase I, pilot and early phase II trials. This includes the evaluation of pharmacokinetics and biological correlates of the activity of these agents or approaches. As an example, for the past 5 years, I have been working on evaluation of crizotinib as an ALK, ROS1, and MET inhibitor. I am also especially interested in the development of new theraputic approaches for gastrointestestional malignancies. I have an interest in designing and implementing systems to improve the quality and performance of clinical trials. This includes the development and utlization of computerized systems whenever possible. This involves close collaboration with a large group of individuals involved in the clinical research process.

Publications

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