DF/HCC Program Affiliation

Neuro-Oncology

Research Abstract

Primary interests are 1) Genetics and Biology of Gliomas: Indentifcation of genetic and biological markers of tumor type to aid in better diagnosis and more accurate prognosis of gliomas, and use of biolgical markers to distinguish between recurrent tumor and reactive gliosis. Current research includes subclassification of gliomas using developmentally regulated antigens GFAP, A2B5, O4, Gal-C, Fibronectin, neurofilament 160 kD, and Vimentin, and use of gene chip technology to better define gene expression in gliomas. 2) Meningiomas: Studies underway include a medical history study of 200 female meningioma patients from BWH, which reveals that women with transitional and fibroblastic meningiomas have a larger number if conditions indicative of high systemic estrogen then patients with other types of meningiomas. A second collaborative questionnaire study of over 350 women in 42 states and 12 foreign countries is in progress. Preliminary analysis suggests that there may be environmental factors associated with meningioma growth. A third study seeks to correlate expression of estrogen and progestrone receptor status in the meningiomas of the 200 paitients included in the medical history study, in order to determine the specific role of these receptors in tumor growht. 3) Translational research in brain tumors: It is our goal to study and characterize the effects of signal transduction molecules that normally control the growth and differentiation of specific types of cells in the CNS, and to bring these agents to clinical trial. Agents being brought to Phase I clinical trials include the gangioside GM3, retinoic acid, adeno-assciated virally delivered angiostatin and endostatin. 4) Imaging technology: Several novel imaging technologies have been developed at BWH, which allow for improved resection of brain tumors. These inlcude the world's first intraoperative MRI, which allows real-time udpated images during the surgical procedure, 3-D reconstruction of anatomical structures from standard imaging studies, which allows for accurate surgical planning and projection of images onto the surgical field for improved resection, and funcational brain mapping to aid in avoiding functional deficits due to surgery.
Lab url: http://blacklab.bwh.harvard.edu/

Publications

• Smith ER, Manfredi M, Scott RM, Black PM, Moses MA.A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report.Neurosurgery 2007 Jun;60(6):E1148-9; discussion E1149.
  17538362
• Kesari S, Schiff D, Doherty L, Gigas DC, Batchelor TT, Muzikansky A, O'neill A, Drappatz J, Chen-Plotkin AS, Ramakrishna N, Weiss SE, Levy B, Bradshaw J, Kracher J, Laforme A, Black PM, Folkman J, Kieran M, Wen PY.Phase II study of metronomic chemotherapy
  17452651
• Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK.The 1p-encoded protein stathmin and resistance of malignant gliomas to nit
  17440165
• Cargioli TG, Ugur HC, Ramakrishna N, Chan J, Black PM, Carroll RS.Establishment of an in vivo meningioma model with human telomerase reverse transcriptase.Neurosurgery 2007 Apr;60(4):750-9; discussion 759-60.
  17415213
• Ugur HC, Ramakrishna N, Bello L, Menon LG, Kim SK, Black PM, Carroll RS.Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model.J Neurooncol 2007 Feb 20.
  17310267
• Archip N, Clatz O, Whalen S, Kacher D, Fedorov A, Kot A, Chrisochoides N, Jolesz F, Golby A, Black PM, Warfield SK.Non-rigid alignment of pre-operative MRI, fMRI, and DT-MRI with intra-operative MRI for enhanced visualization and navigation in image-guide
  17289403
• Marcus KJ, Astrakas LG, Zurakowski D, Zarifi MK, Mintzopoulos D, Poussaint TY, Anthony DC, De Girolami U, Black PM, Tarbell NJ, Tzika AA.Predicting survival of children with CNS tumors using proton magnetic resonance spectroscopic imaging biomarkers.Int J
  17273766
• Yu Y, Jiang X, Schoch BS, Carroll RS, Black PM, Johnson MD.Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma.Cancer Res 2007 Jan 1;67(1):130-8.
  17210692
• Rajaraman P, Stewart PA, Samet JM, Schwartz BS, Linet MS, Zahm SH, Rothman N, Yeager M, Fine HA, Black PM, Loeffler J, Shapiro WR, Selker RG, Inskip PD.Lead, genetic susceptibility, and risk of adult brain tumors.Cancer Epidemiol Biomarkers Prev 2006 Dec;
  17164378
• Santagata S, Kesari S, Black PM, Chan JA.Anaplastic variant of medulloblastoma mimicking a vestibular schwannoma.J Neurooncol 2007 Jan;81(1):49-51.
  17146596
• Maher EA, Brennan C, Wen PY, Durso L, Ligon KL, Richardson A, Khatry D, Feng B, Sinha R, Louis DN, Quackenbush J, Black PM, Chin L, DePinho RA.Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct mo
  17114236
• Liu F, Park PJ, Lai W, Maher E, Chakravarti A, Durso L, Jiang X, Yu Y, Brosius A, Thomas M, Chin L, Brennan C, DePinho RA, Kohane I, Carroll RS, Black PM, Johnson MD.A genome-wide screen reveals functional gene clusters in the cancer genome and identifies
  17090523
• Bluhm EC, Zahm SH, Fine HA, Black PM, Loeffler JS, Shapiro WR, Selker RG, Inskip PD.Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults.Am J Epidemiol 2007 Jan 1;165(1):63-71.
  17079691
• Dimaio SP, Archip N, Hata N, Talos IF, Warfield SK, Majumdar A, Mcdannold N, Hynynen K, Morrison PR, Wells WM, Kacher DF, Ellis RE, Golby AJ, Black PM, Jolesz FA, Kikinis R.Image-guided neurosurgery at Brigham and Women's Hospital.IEEE Eng Med Biol Mag 20
  17020201
• Kim SK, Kim SU, Park IH, Bang JH, Aboody KS, Wang KC, Cho BK, Kim M, Menon LG, Black PM, Carroll RS.Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression.Clin Cancer Res 2006 Se
  17000692
• Chakravarti A, Erkkinen MG, Nestler U, Stupp R, Mehta M, Aldape K, Gilbert MR, Black PM, Loeffler JS.Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms.Clin Cancer Res 2006 Aug 1;12(15):4738-46.
  16899625
• Talos IF, Zou KH, Ohno-Machado L, Bhagwat JG, Kikinis R, Black PM, Jolesz FA.Supratentorial low-grade glioma resectability: statistical predictive analysis based on anatomic MR features and tumor characteristics.Radiology 2006 May;239(2):506-13.
  16641355
• Ziu M, Schmidt NO, Cargioli TG, Aboody KS, Black PM, Carroll RS.Glioma-produced extracellular matrix influences brain tumor tropism of human neural stem cells.J Neurooncol 2006 Apr 6.
  16598423
• Aboody KS, Najbauer J, Schmidt NO, Yang W, Wu JK, Zhuge Y, Przylecki W, Carroll R, Black PM, Perides G.Targeting of melanoma brain metastases using engineered neural stem/progenitor cells.Neuro-oncol 2006 Apr;8(2):119-26.
  16524944
• Knake S, Halgren E, Shiraishi H, Hara K, Hamer HM, Grant PE, Carr VA, Foxe D, Camposano S, Busa E, Witzel T, Hamalainen MS, Ahlfors SP, Bromfield EB, Black PM, Bourgeois BF, Cole AJ, Cosgrove GR, Dworetzky BA, Madsen JR, Larsson PG, Schomer DL, Thiele EA,
  16516443
• Claus EB, Black PM.Survival rates and patterns of care for patients diagnosed with supratentorial low-grade gliomas: data from the SEER program, 1973-2001.Cancer 2006 Mar 15;106(6):1358-63.
  16470608
• Claus EB, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M, Black PM.Epidemiology of intracranial meningioma.Neurosurgery 2005 Dec;57(6):1088-95; discussion 1088-.
  16331155
• Carroll RS, Zhang J, Bello L, Melnick MB, Maruyama T, McL Black P.KDR activation in astrocytic neoplasms.Cancer 1999 Oct 1;86(7):1335-41.
  10506722