Mark A. Exley, M.S. Ph.D.

Assistant Professor, Department of Medicine, Harvard Medical School

Assistant Professor, Medicine, Beth Israel Deaconess Medical Center

Contact Info

Mark Exley
Beth Israel Deaconess Medical Center
330 Brookline Avenue
Boston, MA, 02215
Mailstop: HIM 925
Phone: 617-667-0982
Fax: 617-667-0610
mexley@bidmc.harvard.edu

Assistant

Susan Cohen
Beth Israel Deaconess Medical Center
330 Brookline Avenue
Boston, MA, 02215
Phone: 617-667-0600
scohen@caregroup.harvard.edu

DF/HCC Program Affiliation

Research Abstract

Publications

• Alatrakchi N, Graham CS, van der Vliet HJ, Sherman KE, Exley MA, Koziel MJ.Hepatitis C Virus (HCV)-Specific CD8+ Cells Produce Transforming Growth Factor {beta} That Can Suppress HCV-Specific T-Cell Responses.J Virol 2007 Jun;81(11):5882-92.
  17376924
• Yue SC, Shaulov A, Wang R, Balk SP, Exley MA.CD1d ligation on human monocytes directly signals rapid NF-kappaB activation and production of bioactive IL-12.Proc Natl Acad Sci U S A 2005 Aug 16;102(33):11811-6.
  16091469
• Durante-Mangoni E, Wang R, Shaulov A, He Q, Nasser I, Afdhal N, Koziel MJ, Exley MA.Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells.J Immunol 2004 Aug 1;173(3):2159-66.
  15265953
• Exley MA, Bigley NJ, Cheng O, Shaulov A, Tahir SM, Carter QL, Garcia J, Wang C, Patten K, Stills HF, Alt FW, Snapper SB, Balk SP.Innate immune response to encephalomyocarditis virus infection mediated by CD1d.Immunology 2003 Dec;110(4):519-26.
  14632651
• Levy O, Orange JS, Hibberd P, Steinberg S, LaRussa P, Weinberg A, Wilson SB, Shaulov A, Fleisher G, Geha RS, Bonilla FA, Exley M.Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in
  14513412
• Exley MA, He Q, Cheng O, Wang RJ, Cheney CP, Balk SP, Koziel MJ.Cutting edge: Compartmentalization of Th1-like noninvariant CD1d-reactive T cells in hepatitis C virus-infected liver.J Immunol 2002 Feb 15;168(4):1519-23.
  11823474
• Exley MA, Tahir SM, Cheng O, Shaulov A, Joyce R, Avigan D, Sackstein R, Balk SP.A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses.J Immunol 2001 Nov 15;167(10):5531-4.
  11698421
• Tahir SM, Cheng O, Shaulov A, Koezuka Y, Bubley GJ, Wilson SB, Balk SP, Exley MA.Loss of IFN-gamma production by invariant NK T cells in advanced cancer.J Immunol 2001 Oct 1;167(7):4046-50.
  11564825
• Exley MA, Bigley NJ, Cheng O, Tahir SM, Smiley ST, Carter QL, Stills HF, Grusby MJ, Koezuka Y, Taniguchi M, Balk SP.CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus.J Leukoc Biol 2001 May;6
  11358978
• Exley M, Garcia J, Wilson SB, Spada F, Gerdes D, Tahir SM, Patton KT, Blumberg RS, Porcelli S, Chott A, Balk SP.CD1d structure and regulation on human thymocytes, peripheral blood T cells, B cells and monocytes.Immunology 2000 May;100(1):37-47.
  10809957
• Exley M, Garcia J, Balk SP, Porcelli S.Requirements for CD1d recognition by human invariant Valpha24+ CD4-CD8- T cells.J Exp Med 1997 Jul 7;186(1):109-20.
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