
Michael B. Atkins, M.D.
Professor, Department of Medicine, Harvard Medical School
Director, Cutaneous Oncology and Biologic Therapy Programs and Clinical Res, Beth Israel Deaconess Medical Center
Contact Info
Michael Atkins
Dana-Farber Cancer Institute
375 Longwood Ave.
Boston, MA, 02215
Mailstop: MASCO 415
Phone: 617-632-9250
Fax: 617-632-9260
matkins@bidmc.harvard.edu
Administrative Assistant
Cutaneous Oncology and Biologic Therapy Programs and Clinical Res
Beth Israel Deaconess Medical Center
375 Longwood Ave.
Boston, MA, 02215
Phone: 617-632-9270
Fax: 617-632-9260
sgraham@caregroup.harvard.edu
Dana-Farber Cancer Institute
375 Longwood Ave.
Boston, MA, 02215
Mailstop: MASCO 415
Phone: 617-632-9250
Fax: 617-632-9260
matkins@bidmc.harvard.edu
Assistant
Susan Graham-McLaughlinAdministrative Assistant
Cutaneous Oncology and Biologic Therapy Programs and Clinical Res
Beth Israel Deaconess Medical Center
375 Longwood Ave.
Boston, MA, 02215
Phone: 617-632-9270
Fax: 617-632-9260
sgraham@caregroup.harvard.edu
DF/HCC Program Affiliation
Cancer ImmunologyCutaneous Oncology and Melanoma
Kidney Cancer, Leader
Translational Pharmacology and Early Therapeutic Trials
DF/HCC Associations
Principal Investigator, Kidney Cancer SPOREMember, Center Scientific Council
Research Abstract
Dr. Atkins is a clinical investigator with a primary interest in biologic therapies for malignant disease. Dr. Atkins played a key role in the clinical development of IL-2 from the early Phase I trials to its eventual approval by the FDA as the standard therapy for metastatic renal cell carcinoma and melanoma. His group has also conducted both Phase I and Phase II trials with interelukin-4 interleukin-6, and interleukin-12. Current clinical research efforts focus on defining the role of IL-2 and chemotherapy combinations (biochemotherapy) in melanoma, the need for high-dose IL-2 in metastatic RCCA, the role of IL-2 in the adjuvant setting in RCCA, and further approaches to modulate cytokine related toxicity. Additional activities include the first clinical trials combining IL-2 and IL-12 and the investigation of dendritic cell:tumor cell fusion vaccines in patient with melanoma. Related laboratory investigations are examining the mechanisms underlying IL-12 induced tolerance, IL-12 and IL-2 synergy, the resistance of RCCA to IL-2, and the factorsresponsible for synergy between biologic agents and chemotherapy in melanoma. These clinical and laboratory studies are providing considerable insight into the complex biologic and immunologic effects of this important new class of cancer therapies.
Publications
- Atkins MB, Elder DE, Essner R, Flaherty KT, Gajewski TF, Haluska FG, Hwu P, Keilholz U, Kirkwood JM, Mier JW, Ross MI, Slingluff CL, Sondak VK, Sosman JA, Weinstock MA, King L.Innovations and challenges in melanoma: summary statement from the first Cambri
16609047 - Atkins MB, Robertson MJ, Gordon M, Lotze MT, DeCoste M, DuBois JS, Ritz J, Sandler AB, Edington HD, Garzone PD, Mier JW, Canning CM, Battiato L, Tahara H, Sherman ML.Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advan
9815699 - McDermott DF, Trehu EG, Mier JW, Sorce D, Rand W, Ronayne L, Kappler K, Clancy M, Klempner M, Atkins MB.A two-part phase I trial of high-dose interleukin 2 in combination with soluble (Chinese hamster ovary) interleukin 1 receptor.Clin Cancer Res 1998 May
9607578




