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Kai W. Wucherpfennig, MD, PhD

Professor, Department of Neurology, Harvard Medical School

Professor and Co-chair, Cancer Immunology & AIDS, Dana-Farber Cancer Institute

Contact Info

Kai Wucherpfennig
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Mailstop: Smith 736
Phone: 617-632-3086
kai_wucherpfennig@dfci.harvard.edu

Assistant

Charles Thomas
Dana-Farber Cancer Institute
Phone: 617-632-6659
charlesa_thomas@dfci.harvard.edu

DF/HCC Program Affiliation

Cancer Immunology, Co-Leader

DF/HCC Associations

Member, Center Scientific Council

Lab Website

Wucherpfennig lab

Research Abstract

T cells play a central role in cancer immunotherapy. They have the ability to specifically detect and selectively destroy cancer cells following recognition of a tumor antigen. We work on the mechanisms that constrain the activity of cytotoxic T cells in the tumor microenvironment. Using an in vivo shRNA screen, we have identified a series of negative regulators of T cell function in tumors. Our work focuses on the molecular mechanisms by which these genes inhibit T cell function against tumors and the development of novel cancer immunotherapies based on this insights.

Publications

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