Kai W. Wucherpfennig, MD, PhD
Professor, Department of Neurology, Harvard Medical School
Professor, Cancer Immunology & AIDS, Dana-Farber Cancer Institute
DF/HCC Program AffiliationCancer Immunology
Member, Center Scientific Council
T cell recognition of self-antigens is a key step in the development of human autoimmune diseases. Susceptibility to a variety of human autoimmune diseases is associated with particular alleles of MHC class II genes. The goal of the research is to define the mechanisms by which MHC genes confer susceptibility to autoimmunity. An important aspect is the characterization of self-peptides that are presented by these MHC molecules and recognized by T cells in autoimmune diseases. An understanding of the mechanisms that result in spontaneous T cell responses to self-antigens in autoimmunity may have implications for the identification of appropriate target antigens for cancer immunotherapy.
View All Publications