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Kai W. Wucherpfennig, MD, PhD

Professor, Department of Neurology, Harvard Medical School

Professor, Cancer Immunology & AIDS, Dana-Farber Cancer Institute

Contact Info

Kai Wucherpfennig
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Mailstop: Dana 1410
Phone: 617-632-3086
Fax: 617-632-2662


Julianne Deluca
Dana-Farber Cancer Institute
Phone: 617-632-3856

DF/HCC Program Affiliation

Cancer Immunology, Co-Leader

DF/HCC Associations

Member, Center Scientific Council

Research Abstract

T cell recognition of self-antigens is a key step in the development of human autoimmune diseases. Susceptibility to a variety of human autoimmune diseases is associated with particular alleles of MHC class II genes. The goal of the research is to define the mechanisms by which MHC genes confer susceptibility to autoimmunity. An important aspect is the characterization of self-peptides that are presented by these MHC molecules and recognized by T cells in autoimmune diseases. An understanding of the mechanisms that result in spontaneous T cell responses to self-antigens in autoimmunity may have implications for the identification of appropriate target antigens for cancer immunotherapy.


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