DF/HCC Program Affiliation

Gastrointestinal Malignancies, Co-Leader
Cutaneous Oncology and Melanoma

DF/HCC Associations

Member, Center Scientific Council

Research Abstract

Our laboratory research focus is on viral oncolysis of solid tumors. We have examined Herpes simplex virus 1 immediately early gene regulation as a strategy to achieve preferential HSV-1 replication in transformed cells compared to normal cells. We are also involved in integration of specific therapeutic transgenes into these viral mutants. The laboratory work centers on genetic engineering of viral mutants, preclinical characterization, and clinical trials of viral oncolytic gene therapy.

Publications

• Blanchard K, Colbert JA, Kopans DB, Moore R, Halpern EF, Hughes KS, Smith BL, Tanabe KK, Michaelson JS.Long-term risk of false-positive screening results and subsequent biopsy as a function of mammography use.Radiology 2006 Aug;240(2):335-42.
  16864665
• Takahashi K, Eto H, Tanabe KK.Involvement of CD44 in matrix metalloproteinase-2 regulation in human melanoma cells.Int J Cancer 1999 Jan 29;80(3):387-95.
  9935179
• Yoon SS, Carroll NM, Chiocca EA, Tanabe KK.Cancer gene therapy using a replication-competent herpes simplex virus type 1 vector.Ann Surg 1998 Sep;228(3):366-74.
  9742919