DF/HCC Program Affiliation

Cutaneous Oncology and Melanoma
Lymphoma and Myeloma
Kidney Cancer
Leukemia
Cancer Immunology
Translational Pharmacology and Early Therapeutic Trials

DF/HCC Associations

BIDMC, Transplant, Clinical Trial Chairs
BIDMC, Leukemia, Clinical Trial Chairs

Research Abstract

My research interest lies in the field of tumor immunotherapy and its incorporation into bone marrow transplantation. Active projects include the development of dendritic cell tumor fusions to be used as tumor vaccines in a clinical trial for patients with breast cancer now in progression. I have also been exploring the number of immune reconstitution post-transplant and studying the impact of cytokine therapy with IL-12 and GM-CSF on this process. I am currently leading a new trial in the use of post-transplant Her2Neu antibody therapy assessing its impact on persistent residual disease. One group is investigating novel approaches to allogeneic transplantation including the use of non-myeloablative approaches.

Publications

• Borges VF, Kufe D, Avigan DE.Update on cancer vaccines.Curr Opin Gastroenterol 2002 Nov;18(6):723-31.
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• Avigan D, Vasir B, Gong J, Borges V, Wu Z, Uhl L, Atkins M, Mier J, McDermott D, Smith T, Giallambardo N, Stone C, Schadt K, Dolgoff J, Tetreault JC, Villarroel M, Kufe D.Fusion cell vaccination of patients with metastatic breast and renal cancer induces
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• Raje N, Hideshima T, Davies FE, Chauhan D, Treon SP, Young G, Tai YT, Avigan D, Gong J, Schlossman RL, Richardson P, Kufe DW, Anderson KC.Tumour cell/dendritic cell fusions as a vaccination strategy for multiple myeloma.Br J Haematol 2004 May;125(3):343-5
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• Avigan D.Fusions of breast cancer and dendritic cells as a novel cancer vaccine.Clin Breast Cancer 2003 Feb;3 Suppl 4:S158-63.
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