DF/HCC Program Affiliation

Neuro-Oncology

Research Abstract

My laboratory has created models of human neurologic diseases including Parkinson's disease and Alzheimer's disease in Drosophila. We are now exploiting genetic analysis in Drosophila to investigate the role of various cellular pathways, most recently control of cell cycle, in these models. My clinical research has also recently focused on the control of cell cycle with studies of the proliferative potential of human astrocytes in the adult and pediatric brain.

Publications

• Dufty BM, Warner LR, Hou ST, Jiang SX, Gomez-Isla T, Leenhouts KM, Oxford JT, Feany MB, Masliah E, Rohn TT.Calpain-Cleavage of {alpha}-Synuclein: Connecting Proteolytic Processing to Disease-Linked Aggregation.Am J Pathol 2007 May;170(5):1725-38.
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• Periquet M, Fulga T, Myllykangas L, Schlossmacher MG, Feany MB.Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.J Neurosci 2007 Mar 21;27(12):3338-46.
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• Steinhilb ML, Dias-Santagata D, Mulkearns EE, Shulman JM, Biernat J, Mandelkow EM, Feany MB.S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila.J Neurosci Res 2007 May 1;85(6):1271-8.
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• Fulga TA, Elson-Schwab I, Khurana V, Steinhilb ML, Spires TL, Hyman BT, Feany MB.Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.Nat Cell Biol 2007 Feb;9(2):139-48.
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• Dias-Santagata D, Fulga TA, Duttaroy A, Feany MB.Oxidative stress mediates tau-induced neurodegeneration in Drosophila.J Clin Invest 2007 Jan;117(1):236-45.
  17173140
• Khurana V, Feany MB.Connecting cell-cycle activation to neurodegeneration in Drosophila.Biochim Biophys Acta 2007 Apr;1772(4):446-56.
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• Gavin BA, Dolph MJ, Deleault NR, Geoghegan JC, Khurana V, Feany MB, Dolph PJ, Supattapone S.Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome.J Neurosci 2006 No
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• Kontopoulos E, Parvin JD, Feany MB.Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity.Hum Mol Genet 2006 Oct 15;15(20):3012-23.
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• Khurana V, Lu Y, Steinhilb ML, Oldham S, Shulman JM, Feany MB.TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.Curr Biol 2006 Feb 7;16(3):230-41.
  16461276
• Orso G, Martinuzzi A, Rossetto MG, Sartori E, Feany M, Daga A.Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine.J Clin Invest 2005 Nov;115(11):3026-34.
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