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Andrew H. Lichtman, MD, PhD

Professor, Department of Pathology, Harvard Medical School

Contact Info

Andrew Lichtman
Brigham And Women's Hospital
221 Longwood Avenue
Boston, MA, 02115
Mailstop: LMRC-521
Phone: 617-732-6532
Fax: 617-732-5795
alichtman@rics.bwh.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Cancer Immunology

Research Abstract

Our laboratory investigates the regulation of T cell mediated immune responses. One project focuses on functional interactions between endothelium and T lymphocytes. We study how vascular endothelial cells support selective recruitment and activation of different T cell subsets. Recent work focuses on the differential expression among T cell subsets of functional ligands for endothelial selectins. In vivo approaches include studies of peripheral recruitment of adoptively transferred mouse T cells in normal mice and adoptively transferred human T cells in human skin grafted onto SCID mice. A second major project in the laboratory concerns cytokine gene regulation in helper T cell subsets: The aim of this project is to determine the molecular basis for differential cytokine gene expression in helper T cell subsets. Studies are focused on the transcriptional regulation of IL-4 and interferon-gamma gene expression during and after mouse T cell subset differentation.

Publications

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