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Priscilla L. Yang, PhD

Associate Professor, Department of Microbiology and Immunobiology, Harvard Medical School

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Priscilla Yang
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DF/HCC Program Affiliation

Cancer Cell Biology

Lab Website

Yang Research Group

Research Abstract

My group studies mammalian viruses that are significant causes of morbidity and mortality in humans, in particular hepatitis B virus (HBV), hepatitis C virus (HCV), and dengue virus. I have been especially interested in using chemical tools to elucidate molecular mechanisms underlying the replication of viral pathogens and then using this knowledge to pioneer and validate new antiviral targets and strategies. Current themes in my laboratory include the use of small molecules and RNAi as complementary tools to interrogate the role of specific host factors in viral replication; the use of mass spectrometry-based methods to investigate the structure and function of specific lipids in viral replication; the use of activity-based chemoproteomic profiling to characterize virus-induced changes in the host NTPome; the exploitation of the host reactive “cysteineome” to develop irreversible, host-targeted antiviral compounds; and the investigation of polypharmacology as a strategy to develop more effective antivirals with higher barriers to resistance.


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