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James E. Bradner, MD

Assistant Professor, Department of Medicine, Harvard Medical School

Instructor in Medicine, Hematologic Neoplasia/Malignancies, Dana-Farber Cancer Institute

Contact Info

James Bradner
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA, 02215
Phone: 617-632-6629
Fax: 617-278-2140
jbradner@partners.org

Assistant

Dianna Kobierski
Administrative Coordinator
Bradner Labs
Harvard Medical School
200 Longwood Avenue
Boston, MA, 02115
Mailstop: Armenise Building #641
Phone: 617-432-5024
Fax: 617-432-5036
Dkobierski@partners.org

DF/HCC Program Affiliation

Lymphoma and Myeloma
Translational Pharmacology and Early Therapeutic Trials

Lab Website

Bradner Laboratory

Research Abstract

Dr. Bradner is a physician-scientist exploring the interface between chemical biology and molecular oncology. Presently, he is affiliated with the Chemical Biology Program at the Broad Institute of Harvard and MIT and the Division of Hematologic Neoplasia at the Dana-Farber Cancer Institute. The primary focus of his laboratory research concerns the identification of selective small molecules antagonizing enzymatic components of chromatin remodeling complexes. In addition, he is using forward chemical genetic approaches to explore protein catabolism in the cancer cell. These approaches require the development of novel, high-throughput screening techniques and the use of structure-activity relationship models informing the synthesis of focused chemical libraries. The primary focus of his clinical work is the early-phase development of targeted strategies in hematology. He is a staff physician at the Dana-Farber Cancer Institute and attends on the allogeneic stem cell transplantation service.

Publications

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