James E. Bradner, MD
Assistant Professor, Department of Medicine, Harvard Medical School
Instructor in Medicine, Hematologic Neoplasia/Malignancies, Dana-Farber Cancer Institute
DF/HCC Program AffiliationLymphoma and MyelomaTranslational Pharmacology and Early Therapeutic Trials
Lab WebsiteBradner Laboratory
Dr. Bradner is a physician-scientist exploring the interface between chemical biology and molecular oncology. Presently, he is affiliated with the Chemical Biology Program at the Broad Institute of Harvard and MIT and the Division of Hematologic Neoplasia at the Dana-Farber Cancer Institute. The primary focus of his laboratory research concerns the identification of selective small molecules antagonizing enzymatic components of chromatin remodeling complexes. In addition, he is using forward chemical genetic approaches to explore protein catabolism in the cancer cell. These approaches require the development of novel, high-throughput screening techniques and the use of structure-activity relationship models informing the synthesis of focused chemical libraries. The primary focus of his clinical work is the early-phase development of targeted strategies in hematology. He is a staff physician at the Dana-Farber Cancer Institute and attends on the allogeneic stem cell transplantation service.
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