DF/HCC Program Affiliation

Biostatistics
Gastrointestinal Malignancies
Lung Cancer

Research Abstract

My primary interests lie in novel and creative applications of biostatistics to translational and clinical areas of oncology. While I have extensive expertise and experience in the design and analysis of cancer clinical trials, I have a increasing interest in translational research. My translational efforts are focused on the DF/HCC SPORE in Lung Cancer and the multi-disciplinary program in the etiology, pathobiology and therapy of mesothelioma based at BWH. I also work with DF/HCC investigators on specific projects in thoracic cancers and, more recently, in gastrointestinal malignancies. In addition to serving as the clinical trails statistician for the Program Project in Proton Radiation Therapy Research, my research at the MGH Cancer Center includes molecular epidemiology of esophageal cancer as well as clincal and translational collaborations in bone marrow transplantation.

Publications

• Ballen KK, Becker PS, Yeap BY, Matthews B, Henry DH, Ford PA.Autologous stem-cell transplantation can be performed safely without the use of blood-product support.J Clin Oncol 2004 Oct 15;22(20):4087-94.
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• Jänne PA, Gurubhagavatula S, Yeap BY, Lucca J, Ostler P, Skarin AT, Fidias P, Lynch TJ, Johnson BE.Outcomes of patients with advanced non-small cell lung cancer treated with gefitinib (ZD1839, "Iressa") on an expanded access study.Lung Cancer 20
  15084387
• Daly A, McAfee S, Dey B, Colby C, Schulte L, Yeap B, Sackstein R, Tarbell NJ, Sachs D, Sykes M, Spitzer TR.Nonmyeloablative bone marrow transplantation: Infectious complications in 65 recipients of HLA-identical and mismatched transplants.Biol Blood Marro
  12813445
• Yeap BY, Davidian M.Robust two-stage estimation in hierarchical nonlinear models.Biometrics 2001 Mar;57(1):266-72.
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