DF/HCC Program Affiliation

Neuro-Oncology

Research Abstract

A major focus in our laboratory is the role of the erbB receptors and their ligands, the neuregulins, in the development and function of the nervous system. Using molecular and cellular biological techniques, as well as genetically modified mice we are studying the role of erbB receptor signaling in glial poliferation, differentiation and function. Since overexpression of erbB receptors (in particular erbB2/neu) can lead to oncogenesis we are also studying the molecular mechanisms that regulate the expression of these receptors.

Publications

• Sugawara M, Murtie JC, Stankovic KM, Liberman MC, Corfas G.Dynamic patterns of neurotrophin 3 expression in the postnatal mouse inner ear.J Comp Neurol 2007 Mar 1;501(1):30-7.
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• Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G.Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain.Cell 2006 Oct 6;127(1):185-97.
  17018285
• Rieff HI, Corfas G.ErbB receptor signalling regulates dendrite formation in mouse cerebellar granule cells in vivo.Eur J Neurosci 2006 Apr;23(8):2225-9.
  16630068
• Patten BA, Sardi SP, Koirala S, Nakafuku M, Corfas G.Notch1 signaling regulates radial glia differentiation through multiple transcriptional mechanisms.J Neurosci 2006 Mar 22;26(12):3102-8.
  16554461
• Chen S, Velardez MO, Warot X, Yu ZX, Miller SJ, Cros D, Corfas G.Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function.J Neurosci 2006 Mar 22;26(12):3079-86.
  16554459
• Ge W, He F, Kim KJ, Blanchi B, Coskun V, Nguyen L, Wu X, Zhao J, Heng JI, Martinowich K, Tao J, Wu H, Castro D, Sobeih MM, Corfas G, Gleeson JG, Greenberg ME, Guillemot F, Sun YE.Coupling of cell migration with neurogenesis by proneural bHLH factors.Proc
  16432194
• Rieff HI, Raetzman LT, Sapp DW, Yeh HH, Siegel RE, Corfas G.Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells.J Neurosci 1999 Dec 15;19(24):10757-66.
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