DF/HCC Program Affiliation

Cancer Genetics
Lung Cancer
Biostatistics

DF/HCC Associations

Triage Coordinator, MGH, Biostatistics

Research Abstract

Dr. Finkelstein's research is focused on the development of semi-parametric methodology for analyzing the effect of covariates on failure time distributions that arise in Acquired Immune Deficiency Syndrome (AIDS) and cancer epidemiological studies and clinical trials. She has developed methods for analyzing the failure time distributions from interval censored data. Such interval censored data arise in screening studies, where the infection time is not known exactly, but rather is only known to lie in an interval which is of different length for each individual. Dr. Finkelstein's research has also focused on the development of methods for analyzing animal carcinogenicity experiments. Dr. Finkelstein is the director of Biostatistics at the MGH Cancer Center. In addition, she is the Principal Investigator for the Statistical Coordinating Center for the NCI sponsored Cancer Genetics Network.

Publications

• Stephen AE, Roth SI, Fardo DW, Finkelstein DM, Randolph GW, Gaz RD, Hodin RA.Predictors of an accurate preoperative sestamibi scan for single-gland parathyroid adenomas.Arch Surg 2007 Apr;142(4):381-6.
  17441292
• Rajicic N, Finkelstein DM, Schoenfeld DA,.Survival analysis of longitudinal microarrays.Bioinformatics 2006 Nov 1;22(21):2643-9.
  17032680
• Ferrone CR, Finkelstein DM, Thayer SP, Muzikansky A, Fernandez-delCastillo C, Warshaw AL.Perioperative CA19-9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma.J Clin Oncol 2006 Jun 20;24(18):2897-902.
  16782929
• Matthews AG, Betensky RA, Anton-Culver H, Bowen D, Griffin C, Isaacs C, Kasten C, Mineau G, Nayfield S, Schildkraut J, Strong L, Weber B, Finkelstein DM.Analysis of co-aggregation of cancer based on registry data.Community Genet 2006;9(2):87-92.
  16612058
• Nguyen PL, Chakravarti A, Finkelstein DM, Hochberg FH, Batchelor TT, Loeffler JS.Results of whole-brain radiation as salvage of methotrexate failure for immunocompetent patients with primary CNS lymphoma.J Clin Oncol 2005 Mar 1;23(7):1507-13.
  15735126
• Finkelstein DM, Schoenfeld DA.Combining mortality and longitudinal measures in clinical trials.Stat Med 1999 Jun 15;18(11):1341-54.
  10399200
• Goggins WB, Finkelstein DM, Schoenfeld DA, Zaslavsky AM.A Markov chain Monte Carlo EM algorithm for analyzing interval-censored data under the Cox proportional hazards model.Biometrics 1998 Dec;54(4):1498-507.
  9883548