DF/HCC Program Affiliation

Neuro-Oncology

Research Abstract

The Breakefield laboratory is focusing on the use of vector-mediated gene delivery to elucidate the function of proteins underlying hereditary neoplasias associated with neurofibromatosis and tuberous sclerosis, and to test gene therapy for tumors of the nervous system. This work involves development of novel vectors to enhance gene delivery/expression in tumors, and exploration of combined therapeutic modalities, such as pro-drug activation, anti-angiogenesis, and selectively toxic proteins.

Publications

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