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Xandra O. Breakefield, PhD

Professor, Department of Neurology, Harvard Medical School

Geneticist (Neurology), Molecular Neurogenetics Unit, Massachusetts General Hospital

Contact Info

Xandra Breakefield
Massachusetts General Hospital
149 13th St
Charlestown, MA, 02129
Mailstop: Rm 6216
Phone: 617-726-5728
Fax: 617-724-1537


Suzanne McDavitt
Administrative Assistant
Massachusetts General Hospital
Building 149, 13th St.
Charlestown, MA, 02129
Phone: 617-724-1537
Fax: 617-724-6863

DF/HCC Program Affiliation


Research Abstract

The Breakefield laboratory is focusing on the use of vector-mediated gene delivery to elucidate the function of proteins underlying hereditary neoplasias associated with neurofibromatosis and tuberous sclerosis, and to test gene therapy for tumors of the nervous system. This work involves development of novel vectors to enhance gene delivery/expression in tumors, and exploration of combined therapeutic modalities, such as pro-drug activation, anti-angiogenesis, and selectively toxic proteins.


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