DF/HCC Program Affiliation

Translational Pharmacology and Early Therapeutic Trials
Gastrointestinal Malignancies
Head and Neck Cancer
Lung Cancer

DF/HCC Associations

DFCI, TPETT, Clinical Trial Chairs

Research Abstract

I conduct both basic and translational research on cyclin-dependent kinase inhibitors. A major goal is to define the role of one of these inhibitors, p16ink4a in the cellular response to DNA damage. In addition, I am directing both preclinical and clinical studies of several potent pharmacologic cyclin-dependent kinase inhibitors. Several phase I trials are underway investigating these agents in patients with advanced solid tumors. The work involves the assessment of these drugs alone, as well as in combination with standard chemotherapy agents and signal transduction inhibitors.

Publications

• Haddad RI, Weinstein LJ, Wieczorek TJ, Bhattacharya N, Raftopoulos H, Oster MW, Zhang X, Latham VM, Costello R, Faucher J, DeRosa C, Yule M, Miller LP, Loda M, Posner MR, Shapiro GI.A phase II clinical and pharmacodynamic study of E7070 in patients with m
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• Shapiro GI.Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol.Clin Cancer Res 2004 Jun 15;10(12 Pt 2):4270s-4275s.
  15217973
• Jiang J, Matranga CB, Cai D, Latham VM, Zhang X, Lowell AM, Martelli F, Shapiro GI.Flavopiridol-induced apoptosis during S phase requires E2F-1 and inhibition of cyclin A-dependent kinase activity.Cancer Res 2003 Nov 1;63(21):7410-22.
  14612540
• Matranga CB, Shapiro GI.Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase.Cancer Res 2002 Mar 15;62(6):1707-17.
  11912144
• Shapiro GI, Koestner DA, Matranga CB, Rollins BJ.Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small cell lung cancer cell lines.Clin Cancer Res 1999 Oct;5(10):2925-38.
  10537362
• Shapiro GI, Edwards CD, Ewen ME, Rollins BJ.p16INK4A participates in a G1 arrest checkpoint in response to DNA damage.Mol Cell Biol 1998 Jan;18(1):378-87.
  9418885
• Shapiro GI, Park JE, Edwards CD, Mao L, Merlo A, Sidransky D, Ewen ME, Rollins BJ.Multiple mechanisms of p16INK4A inactivation in non-small cell lung cancer cell lines.Cancer Res 1995 Dec 15;55(24):6200-9.
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