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Jeffrey W. Harper, PhD

Professor, Department of Cell Biology, Harvard Medical School

Contact Info

Jeffrey Harper
Harvard Medical School
77 Avenue Louis Pasteur
Boston, MA, 02115
Mailstop: NRB, 940
Phone: 617-432-6590
Fax: 617-432-6591
wade_harper@hms.harvard.edu

Assistant

Not Available.

DF/HCC Program Affiliation

Cancer Cell Biology

DF/HCC Associations

Member, Center Scientific Council
Director, DNA Resource

Research Abstract

My work is focused on understanding how the cell division cycle is controlled. We study the regulation of cyclin-dependent kinases and their inhibitors as well as other signalling pathways controlled by protein kinases. Much of this regulation occurs through protein turnover through the ubiquitin pathway. My lab is interested in the control of protein turnover through the SCF ubiquitin ligases. In recent years, we have identified ubiquitin ligases for I-kappa B, beta-catenin, cyclin E, and Cdc25, key regulators of cell division and survival. Currently, genomic and biochemical approaches are being used to dissect how that activities of these and other processes are controlled.

Publications

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