DF/HCC Program Affiliation

Cancer Cell Biology

Research Abstract

We are interested in the biological function and mechanism of action of a number of transcriptional regulators that are targets of viral oncoproteins. These proteins include p300/CBP, CtBP and YY1. We are using both genetic (C. elegans and mouse) and biochemical approaches to address relevant questions.

Publications

• Horwitz AA, Affar el B, Heine GF, Shi Y, Parvin JD.A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase.Proc Natl Acad Sci U S A 2007 Apr 17;104(16):6614-9.
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• Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y.The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.Cell 2007 Mar 23;128(6):1077-88.
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• Donohoe ME, Zhang LF, Xu N, Shi Y, Lee JT.Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch.Mol Cell 2007 Jan 12;25(1):43-56.
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• Sui GC, Affar EB, Shi YJ, Wall N, Brignone C, Yin P, Dohonoe M, Calvo D, Grossman S, Shi Y.Yin Yang 1 is a negative regulator of p53.Cell 2004 June 25;117:859-872.
• Shi YJ, Sawada JI, Su GC, Affar EB, Whetstine J, Lan F, Ogawa H, Luke M, Nakatani Y, Shi, Y.Coordinated histone modifications mediated by a CtBP co-repressor complex.Nature 2003 Apr 17;422:735-738.
• Sui G, Soohoo C, Affar el B, Gay F, Shi Y, Forrester WC, Shi Y.A DNA vector-based RNAi technology to suppress gene expression in mammalian cells.Proc Natl Acad Sci U S A 2002 Apr 16;99(8):5515-20.
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