DF/HCC Program Affiliation

Head and Neck Cancer

Research Abstract

My laboratory research focuses on the molecular mechanisms of interaction of radiation and chemotherapeutic drugs, particularly the taxanes. Current projects are examining the role of the tumor suppressor p53 and bcl-2 related proteins on the interaction of Taxol and radiation in human tumor cells. We are also examining other chemotherapy-radiaton interactions, as well as different aspects of radiation-dependent gene induction. My clinical reasearch interests are: 1) use of combined modality treatment for organ preservation in the treatment of head and neck cancers 2) role of radiation sensitizers and chemotherapeutic drugs in treatment of tumors of the central nervous system.

Publications

• Tishler RB, Busse PM, Norris CM, Rossi R, Poulin M, Thornhill L, Costello R, Peters ES, Colevas AD, Posner MR.An initial experience using concurrent paclitaxel and radiation in the treatment of head and neck malignancies.Int J Radiat Oncol Biol Phys 1999
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• Tishler RB, Lamppu DM, Park S, Price BD.Microtubule-active drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53.Cancer Res 1995 Dec 15;55(24):6021-5.
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• Tishler RB, Geard CR, Hall EJ, Schiff PB.Taxol sensitizes human astrocytoma cells to radiation.Cancer Res 1992 Jun 15;52(12):3495-7.
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