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David M. Livingston, MD

Emil Frei Professor of Medicine, Department of Medicine, Harvard Medical School

Professor, Department of Genetics, Harvard Medical School

Chairman, Executive Committee for Research, Dana-Farber Cancer Institute

Contact Info

David Livingston
Dana-Farber Cancer Institute
450 Brookline Ave
Boston, MA, 02215-5450
Mailstop: SM870
Phone: 617-632-3074
Fax: 617-632-4381
david_livingston@dfci.harvard.edu

Assistant

Nancy Gerard
Executive Support to Dr. David Livingston, M.D.
Cancer Biology
Dana-Farber Cancer Institute
450 Brookline Ave
Boston, MA, 02215-5450
Mailstop: SM 870
Phone: 617-582-8485
Fax: 617-632-4381
nancy_gerard@dfci.harvard.edu

DF/HCC Program Affiliation

Cancer Genetics
Breast Cancer

DF/HCC Associations

Member, Center Scientific Council
Deputy Director, Dana-Farber/Harvard Cancer Center, Executive Committee
Member, Clinical Science Coordinating Committee

Research Abstract

My research program is aimed at understanding the functional properties of four sets of nuclear proteins, each of which plays a major role in the suppression by human cells of certain transformed/neoplastic characteristics. They are the pocket protein family (pRB, p107, p130); p300 and CBP; p400 and TRRAP; and BRCA1 and 2. Analysis of the functions of BRCA1 and 2 as breast/ovarian cancer suppressing elements serve as our link to the Breast Cancer Program, and the work on the other three sets of transformation suppressing proteins underlie our participation in the Cancer Cell Biology Program. Futhermore, our laboratory contributes to an ongoing nodal point interaction between these two Programs. We are also working on converting elements of recent discovery of p300/CBP function into new screens for small molecule agents that interfere with hypoxia-driven tumor survival/proliferation responses.

Publications

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